Paracrine Mechanisms of Redox Signalling for Postmitotic Cell and Tissue Regeneration

Arnau Hervera, Celio X. Santos, Francesco De Virgiliis, Ajay M. Shah*, Simone Di Giovanni

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Adult postmitotic mammalian cells, including neurons and cardiomyocytes, have a limited capacity to regenerate after injury. Therefore, an understanding of the molecular mechanisms underlying their regenerative ability is critical to advance tissue repair therapies. Recent studies highlight how redox signalling via paracrine cell-to-cell communication may act as a central mechanism coupling tissue injury with regeneration. Post-injury redox paracrine signalling can act by diffusion to nearby cells, through mitochondria or within extracellular vesicles, affecting specific intracellular targets such as kinases, phosphatases, and transcription factors, which in turn trigger a regenerative response. Here, we review redox paracrine signalling mechanisms in postmitotic tissue regeneration and discuss current challenges and future directions.

Original languageEnglish
Pages (from-to)514-530
Number of pages17
JournalTrends in cell biology
Issue number6
Publication statusE-pub ahead of print - 19 Feb 2019


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