Paradoxical vasodilation during lower body negative pressure in patients with vasodepressor carotid sinus syndrome

A A Mangoni; E Ouldred; T J Allain; J C T Close; D Hilton; C G Swift; D Lyons; S H D Jackson

doi:10.1046/j.1365-2389.2003.51269.x

Paradoxical vasodilation during lower body negative pressure in patients with vasodepressor carotid sinus syndrome

A A Mangoni, E Ouldred, T J Allain, J C T Close, D Hilton, C G Swift, D Lyons, S H D Jackson

King's College London

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

OBJECTIVES: To elucidate the pathophysiological mechanism of the vasodepressor form (VD) of carotid sinus syndrome (CSS) by maneuvers designed to induce generalized sympathetic activation after baroreceptor unloading (lower body negative pressure, LBNP) or direct peripheral adrenoreceptor stimulation via local administration of norepinephrine (NA). DESIGN: Subjects were identified with VD of CSS through diagnostic testing. SETTING: Research laboratory. PARTICIPANTS: Eleven young controls (YC) (mean age +/- standard error of mean = 22.8 +/- 0.7), eight elderly controls (EC) (72.6 +/- 0.6), and eight elderly patients with VD (78.7 +/- 1.7). MEASUREMENTS: Forearm arterial blood flow (FABF) was measured in the left and right arms by venous occlusion plethysmography. Measurements were performed during baseline conditions, LBNP (-20 mmHg), and intra-arterial NA infusion in the left brachial artery at three progressively increasing rates (60, 120, and 240 pmol/min). RESULTS: During LBNP, FABF significantly decreased in YC (baseline 3.61 +/- 0.30 vs -20 mmHg 2.96 +/- 0.24 mL/100 g/min, P = .030) and EC (4.05 +/- 0.74 vs 3.69 +/- 0.65 mL/100 g/min, P = .033) but increased in elderly patients with VD (3.65 +/- 0.60 vs 4.54 +/- 0.80 mL/100 g/min, P = .020). During NA infusion, a significant forearm vasoconstriction occurred in YC (FABF left:right ratio 1.00 +/- 0.05 at baseline; 0.81 +/- 0.08 at 60 pmol/min, P = .034; 0.81 +/- 0.05 at 120 pmol/min, P <.001; 0.72 +/- 0.04 at 240 pmol/min, P <.001), whereas no significant FABF changes were observed in EC (1.04 +/- 0.06; 0.96 +/- 0.07, P = .655; 0.89 +/- 0.10, P = .401; 0.94 +/- 0.10, P = .590) or elderly patients with VD (1.04 +/- 0.06; 1.16 +/-0 .10, P = .117; 1.04 +/- 0.08, P = .602; 1.11 +/- 0.10, P = .305). CONCLUSION: VD of CSS is associated with a paradoxical vasodilatation during LBNP and an impairment of peripheral alpha-adrenergic responsiveness, which may be age-related.

Original language	English
Pages (from-to)	853 - 857
Number of pages	5
Journal	Journal of the American Geriatrics Society
Volume	51
Issue number	6
DOIs	https://doi.org/10.1046/j.1365-2389.2003.51269.x
Publication status	Published - 1 Jun 2003

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@article{1b6ef76366704d2d869fda0b062bd9fc,

title = "Paradoxical vasodilation during lower body negative pressure in patients with vasodepressor carotid sinus syndrome",

abstract = "OBJECTIVES: To elucidate the pathophysiological mechanism of the vasodepressor form (VD) of carotid sinus syndrome (CSS) by maneuvers designed to induce generalized sympathetic activation after baroreceptor unloading (lower body negative pressure, LBNP) or direct peripheral adrenoreceptor stimulation via local administration of norepinephrine (NA). DESIGN: Subjects were identified with VD of CSS through diagnostic testing. SETTING: Research laboratory. PARTICIPANTS: Eleven young controls (YC) (mean age +/- standard error of mean = 22.8 +/- 0.7), eight elderly controls (EC) (72.6 +/- 0.6), and eight elderly patients with VD (78.7 +/- 1.7). MEASUREMENTS: Forearm arterial blood flow (FABF) was measured in the left and right arms by venous occlusion plethysmography. Measurements were performed during baseline conditions, LBNP (-20 mmHg), and intra-arterial NA infusion in the left brachial artery at three progressively increasing rates (60, 120, and 240 pmol/min). RESULTS: During LBNP, FABF significantly decreased in YC (baseline 3.61 +/- 0.30 vs -20 mmHg 2.96 +/- 0.24 mL/100 g/min, P = .030) and EC (4.05 +/- 0.74 vs 3.69 +/- 0.65 mL/100 g/min, P = .033) but increased in elderly patients with VD (3.65 +/- 0.60 vs 4.54 +/- 0.80 mL/100 g/min, P = .020). During NA infusion, a significant forearm vasoconstriction occurred in YC (FABF left:right ratio 1.00 +/- 0.05 at baseline; 0.81 +/- 0.08 at 60 pmol/min, P = .034; 0.81 +/- 0.05 at 120 pmol/min, P <.001; 0.72 +/- 0.04 at 240 pmol/min, P <.001), whereas no significant FABF changes were observed in EC (1.04 +/- 0.06; 0.96 +/- 0.07, P = .655; 0.89 +/- 0.10, P = .401; 0.94 +/- 0.10, P = .590) or elderly patients with VD (1.04 +/- 0.06; 1.16 +/-0 .10, P = .117; 1.04 +/- 0.08, P = .602; 1.11 +/- 0.10, P = .305). CONCLUSION: VD of CSS is associated with a paradoxical vasodilatation during LBNP and an impairment of peripheral alpha-adrenergic responsiveness, which may be age-related.",

author = "Mangoni, {A A} and E Ouldred and Allain, {T J} and Close, {J C T} and D Hilton and Swift, {C G} and D Lyons and Jackson, {S H D}",

year = "2003",

month = jun,

day = "1",

doi = "10.1046/j.1365-2389.2003.51269.x",

language = "English",

volume = "51",

pages = "853 -- 857",

journal = "Journal of the American Geriatrics Society",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Paradoxical vasodilation during lower body negative pressure in patients with vasodepressor carotid sinus syndrome

AU - Mangoni, A A

AU - Ouldred, E

AU - Allain, T J

AU - Close, J C T

AU - Hilton, D

AU - Swift, C G

AU - Lyons, D

AU - Jackson, S H D

PY - 2003/6/1

Y1 - 2003/6/1

N2 - OBJECTIVES: To elucidate the pathophysiological mechanism of the vasodepressor form (VD) of carotid sinus syndrome (CSS) by maneuvers designed to induce generalized sympathetic activation after baroreceptor unloading (lower body negative pressure, LBNP) or direct peripheral adrenoreceptor stimulation via local administration of norepinephrine (NA). DESIGN: Subjects were identified with VD of CSS through diagnostic testing. SETTING: Research laboratory. PARTICIPANTS: Eleven young controls (YC) (mean age +/- standard error of mean = 22.8 +/- 0.7), eight elderly controls (EC) (72.6 +/- 0.6), and eight elderly patients with VD (78.7 +/- 1.7). MEASUREMENTS: Forearm arterial blood flow (FABF) was measured in the left and right arms by venous occlusion plethysmography. Measurements were performed during baseline conditions, LBNP (-20 mmHg), and intra-arterial NA infusion in the left brachial artery at three progressively increasing rates (60, 120, and 240 pmol/min). RESULTS: During LBNP, FABF significantly decreased in YC (baseline 3.61 +/- 0.30 vs -20 mmHg 2.96 +/- 0.24 mL/100 g/min, P = .030) and EC (4.05 +/- 0.74 vs 3.69 +/- 0.65 mL/100 g/min, P = .033) but increased in elderly patients with VD (3.65 +/- 0.60 vs 4.54 +/- 0.80 mL/100 g/min, P = .020). During NA infusion, a significant forearm vasoconstriction occurred in YC (FABF left:right ratio 1.00 +/- 0.05 at baseline; 0.81 +/- 0.08 at 60 pmol/min, P = .034; 0.81 +/- 0.05 at 120 pmol/min, P <.001; 0.72 +/- 0.04 at 240 pmol/min, P <.001), whereas no significant FABF changes were observed in EC (1.04 +/- 0.06; 0.96 +/- 0.07, P = .655; 0.89 +/- 0.10, P = .401; 0.94 +/- 0.10, P = .590) or elderly patients with VD (1.04 +/- 0.06; 1.16 +/-0 .10, P = .117; 1.04 +/- 0.08, P = .602; 1.11 +/- 0.10, P = .305). CONCLUSION: VD of CSS is associated with a paradoxical vasodilatation during LBNP and an impairment of peripheral alpha-adrenergic responsiveness, which may be age-related.

AB - OBJECTIVES: To elucidate the pathophysiological mechanism of the vasodepressor form (VD) of carotid sinus syndrome (CSS) by maneuvers designed to induce generalized sympathetic activation after baroreceptor unloading (lower body negative pressure, LBNP) or direct peripheral adrenoreceptor stimulation via local administration of norepinephrine (NA). DESIGN: Subjects were identified with VD of CSS through diagnostic testing. SETTING: Research laboratory. PARTICIPANTS: Eleven young controls (YC) (mean age +/- standard error of mean = 22.8 +/- 0.7), eight elderly controls (EC) (72.6 +/- 0.6), and eight elderly patients with VD (78.7 +/- 1.7). MEASUREMENTS: Forearm arterial blood flow (FABF) was measured in the left and right arms by venous occlusion plethysmography. Measurements were performed during baseline conditions, LBNP (-20 mmHg), and intra-arterial NA infusion in the left brachial artery at three progressively increasing rates (60, 120, and 240 pmol/min). RESULTS: During LBNP, FABF significantly decreased in YC (baseline 3.61 +/- 0.30 vs -20 mmHg 2.96 +/- 0.24 mL/100 g/min, P = .030) and EC (4.05 +/- 0.74 vs 3.69 +/- 0.65 mL/100 g/min, P = .033) but increased in elderly patients with VD (3.65 +/- 0.60 vs 4.54 +/- 0.80 mL/100 g/min, P = .020). During NA infusion, a significant forearm vasoconstriction occurred in YC (FABF left:right ratio 1.00 +/- 0.05 at baseline; 0.81 +/- 0.08 at 60 pmol/min, P = .034; 0.81 +/- 0.05 at 120 pmol/min, P <.001; 0.72 +/- 0.04 at 240 pmol/min, P <.001), whereas no significant FABF changes were observed in EC (1.04 +/- 0.06; 0.96 +/- 0.07, P = .655; 0.89 +/- 0.10, P = .401; 0.94 +/- 0.10, P = .590) or elderly patients with VD (1.04 +/- 0.06; 1.16 +/-0 .10, P = .117; 1.04 +/- 0.08, P = .602; 1.11 +/- 0.10, P = .305). CONCLUSION: VD of CSS is associated with a paradoxical vasodilatation during LBNP and an impairment of peripheral alpha-adrenergic responsiveness, which may be age-related.

UR - http://www.scopus.com/inward/record.url?scp=0037639723&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2389.2003.51269.x

DO - 10.1046/j.1365-2389.2003.51269.x

M3 - Article

VL - 51

SP - 853

EP - 857

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

IS - 6

ER -

Paradoxical vasodilation during lower body negative pressure in patients with vasodepressor carotid sinus syndrome

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