Paraneoplastic cicatricial pemphigoid

J Setterfield; P J Shirlaw; Z Lazarova; B M Bryant; B S Bhogal; K Harman; S J Challacombe; M M Black

Paraneoplastic cicatricial pemphigoid

J Setterfield, P J Shirlaw, Z Lazarova, B M Bryant, B S Bhogal, K Harman, S J Challacombe, M M Black

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

We report a 39-year-old woman with antiepiligrin cicatricial pemphigoid (CP) in association with non-small cell carcinoma of the lung. At presentation, mucosal lesions showed minimal response to combined systemic immunosuppressive agents. Following the diagnosis of non-small cell lung carcinoma and subsequent treatment with gemcitabine (a second-line chemotherapeutic agent), a significant reduction in both tumour mass and mucosal blistering was observed. Metastatic disease was subsequently associated with recurrent oral erosions. We believe this patient represents the first reported case of paraneoplastic CP.

Original language	English
Pages (from-to)	127-31
Number of pages	5
Journal	British Journal of Dermatology
Volume	141
Issue number	1
Publication status	Published - Jul 1999

Keywords

Adult
Carcinoma, Non-Small-Cell Lung
Cell Adhesion Molecules
Complement C3
Female
Fluorescent Antibody Technique, Direct
Humans
Immunoglobulin G
Lung Neoplasms
Microscopy, Immunoelectron
Paraneoplastic Syndromes
Pemphigoid, Benign Mucous Membrane
Skin

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title = "Paraneoplastic cicatricial pemphigoid",

abstract = "We report a 39-year-old woman with antiepiligrin cicatricial pemphigoid (CP) in association with non-small cell carcinoma of the lung. At presentation, mucosal lesions showed minimal response to combined systemic immunosuppressive agents. Following the diagnosis of non-small cell lung carcinoma and subsequent treatment with gemcitabine (a second-line chemotherapeutic agent), a significant reduction in both tumour mass and mucosal blistering was observed. Metastatic disease was subsequently associated with recurrent oral erosions. We believe this patient represents the first reported case of paraneoplastic CP.",

keywords = "Adult, Carcinoma, Non-Small-Cell Lung, Cell Adhesion Molecules, Complement C3, Female, Fluorescent Antibody Technique, Direct, Humans, Immunoglobulin G, Lung Neoplasms, Microscopy, Immunoelectron, Paraneoplastic Syndromes, Pemphigoid, Benign Mucous Membrane, Skin",

author = "J Setterfield and Shirlaw, {P J} and Z Lazarova and Bryant, {B M} and Bhogal, {B S} and K Harman and Challacombe, {S J} and Black, {M M}",

year = "1999",

month = jul,

language = "English",

volume = "141",

pages = "127--31",

journal = "British Journal of Dermatology",

issn = "0007-0963",

publisher = "John Wiley & Sons, Ltd (10.1111)",

number = "1",

}

TY - JOUR

T1 - Paraneoplastic cicatricial pemphigoid

AU - Setterfield, J

AU - Shirlaw, P J

AU - Lazarova, Z

AU - Bryant, B M

AU - Bhogal, B S

AU - Harman, K

AU - Challacombe, S J

AU - Black, M M

PY - 1999/7

Y1 - 1999/7

N2 - We report a 39-year-old woman with antiepiligrin cicatricial pemphigoid (CP) in association with non-small cell carcinoma of the lung. At presentation, mucosal lesions showed minimal response to combined systemic immunosuppressive agents. Following the diagnosis of non-small cell lung carcinoma and subsequent treatment with gemcitabine (a second-line chemotherapeutic agent), a significant reduction in both tumour mass and mucosal blistering was observed. Metastatic disease was subsequently associated with recurrent oral erosions. We believe this patient represents the first reported case of paraneoplastic CP.

AB - We report a 39-year-old woman with antiepiligrin cicatricial pemphigoid (CP) in association with non-small cell carcinoma of the lung. At presentation, mucosal lesions showed minimal response to combined systemic immunosuppressive agents. Following the diagnosis of non-small cell lung carcinoma and subsequent treatment with gemcitabine (a second-line chemotherapeutic agent), a significant reduction in both tumour mass and mucosal blistering was observed. Metastatic disease was subsequently associated with recurrent oral erosions. We believe this patient represents the first reported case of paraneoplastic CP.

KW - Adult

KW - Carcinoma, Non-Small-Cell Lung

KW - Cell Adhesion Molecules

KW - Complement C3

KW - Female

KW - Fluorescent Antibody Technique, Direct

KW - Humans

KW - Immunoglobulin G

KW - Lung Neoplasms

KW - Microscopy, Immunoelectron

KW - Paraneoplastic Syndromes

KW - Pemphigoid, Benign Mucous Membrane

KW - Skin

M3 - Article

C2 - 10417528

SN - 0007-0963

VL - 141

SP - 127

EP - 131

JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 1

ER -

Paraneoplastic cicatricial pemphigoid

Abstract

Keywords

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