TY - JOUR
T1 - Parent-mediated intervention in infants with an elevated likelihood for autism reduces dwell time during a gaze-following task
AU - Bedford, Rachael
AU - Green, Jonathan
AU - Gliga, Teodora
AU - Jones, Emily J H
AU - Elsabbagh, Mayada
AU - Pasco, Greg
AU - Wan, Ming Wai
AU - Slonims, Vicky
AU - Charman, Tony
AU - Pickles, Andrew
AU - Johnson, Mark H
AU - BASIS Team
N1 - Publisher Copyright:
© 2024 The Author(s). Autism Research published by International Society for Autism Research and Wiley Periodicals LLC.
PY - 2024/11
Y1 - 2024/11
N2 - Cognitive markers may in theory be more sensitive to the effects of intervention than overt behavioral measures. The current study tests the impact of the Intervention with the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting (iBASIS-VIPP) on an eye-tracking measure of social attention: dwell time to the referred object in a gaze following task. The original two-site, two-arm, assessor-blinded randomized controlled trial (RCT) of this intervention to increase parental awareness, and responsiveness to their infant, was run with infants who have an elevated familial likelihood for autism (EL). Fifty-four EL infants (28 iBASIS-VIPP intervention, 26 no intervention) were enrolled, and the intervention took place between 9 months (baseline) and 15 months (endpoint), with gaze following behavior measured at 15 months. Secondary intention to treat (ITT) analysis showed that the intervention was associated with significantly reduced dwell time to the referent of another person's gaze (β = -0.32, SE = 0.14, p = 0.03) at 15-month treatment endpoint. Given the established link between gaze following and language, the results are considered in the context of a previously reported, non-significant and transient trend toward lower language scores at the treatment endpoint (Green et al. (2015) The Lancet Psychiatry, 2(2), 133-140). Future intervention trials should aim to include experimental cognitive measures, alongside behavioral measures, to investigate mechanisms associated with intervention effects.
AB - Cognitive markers may in theory be more sensitive to the effects of intervention than overt behavioral measures. The current study tests the impact of the Intervention with the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting (iBASIS-VIPP) on an eye-tracking measure of social attention: dwell time to the referred object in a gaze following task. The original two-site, two-arm, assessor-blinded randomized controlled trial (RCT) of this intervention to increase parental awareness, and responsiveness to their infant, was run with infants who have an elevated familial likelihood for autism (EL). Fifty-four EL infants (28 iBASIS-VIPP intervention, 26 no intervention) were enrolled, and the intervention took place between 9 months (baseline) and 15 months (endpoint), with gaze following behavior measured at 15 months. Secondary intention to treat (ITT) analysis showed that the intervention was associated with significantly reduced dwell time to the referent of another person's gaze (β = -0.32, SE = 0.14, p = 0.03) at 15-month treatment endpoint. Given the established link between gaze following and language, the results are considered in the context of a previously reported, non-significant and transient trend toward lower language scores at the treatment endpoint (Green et al. (2015) The Lancet Psychiatry, 2(2), 133-140). Future intervention trials should aim to include experimental cognitive measures, alongside behavioral measures, to investigate mechanisms associated with intervention effects.
UR - http://www.scopus.com/inward/record.url?scp=85202521967&partnerID=8YFLogxK
U2 - 10.1002/aur.3223
DO - 10.1002/aur.3223
M3 - Article
C2 - 39205333
SN - 1939-3806
VL - 17
SP - 2346
EP - 2354
JO - Autism research : official journal of the International Society for Autism Research
JF - Autism research : official journal of the International Society for Autism Research
IS - 11
ER -