Parkinsonian syndromes

K. Ray Chaudhuri; Prashanth Reddy; Kallol Ray Chaudhuri

doi:10.1007/978-1-84996-065-6_2

Parkinsonian syndromes

K. Ray Chaudhuri, Prashanth Reddy, Kallol Ray Chaudhuri

Basic and Clinical Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

A variety of conditions may cause parkinsonian syndromes independent of the idiopathic loss of substantia nigra neurons and deafferentation of the striatum; these include degenerative conditions, infections, drugs, toxins and structural lesions (Figure 2.1). The clinical pictures of these degenerative conditions overlap but are usually recognized by the presence of subtle red flags in the earlier stage of the illness. Over the period of a few years a distinctive atypical clinical picture, separate to that of Parkinson's disease, emerges and is typically characterized by a poorer response to dopaminergic therapy. However, it may be impossible to distinguish idiopathic Parkinson's disease from other parkinsonian syndromes by clinical features alone, although review of the patient's medical history and diagnostic tests, such as sophisticated neuroimaging, can aid diagnosis [1].

Original language	English
Title of host publication	Movement Disorders in Clinical Practice
Publisher	Springer London
Pages	33-47
Number of pages	15
ISBN (Print)	9781849960649
DOIs	https://doi.org/10.1007/978-1-84996-065-6_2
Publication status	Published - 2010

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abstract = "A variety of conditions may cause parkinsonian syndromes independent of the idiopathic loss of substantia nigra neurons and deafferentation of the striatum; these include degenerative conditions, infections, drugs, toxins and structural lesions (Figure 2.1). The clinical pictures of these degenerative conditions overlap but are usually recognized by the presence of subtle red flags in the earlier stage of the illness. Over the period of a few years a distinctive atypical clinical picture, separate to that of Parkinson's disease, emerges and is typically characterized by a poorer response to dopaminergic therapy. However, it may be impossible to distinguish idiopathic Parkinson's disease from other parkinsonian syndromes by clinical features alone, although review of the patient's medical history and diagnostic tests, such as sophisticated neuroimaging, can aid diagnosis [1].",

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AB - A variety of conditions may cause parkinsonian syndromes independent of the idiopathic loss of substantia nigra neurons and deafferentation of the striatum; these include degenerative conditions, infections, drugs, toxins and structural lesions (Figure 2.1). The clinical pictures of these degenerative conditions overlap but are usually recognized by the presence of subtle red flags in the earlier stage of the illness. Over the period of a few years a distinctive atypical clinical picture, separate to that of Parkinson's disease, emerges and is typically characterized by a poorer response to dopaminergic therapy. However, it may be impossible to distinguish idiopathic Parkinson's disease from other parkinsonian syndromes by clinical features alone, although review of the patient's medical history and diagnostic tests, such as sophisticated neuroimaging, can aid diagnosis [1].

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Parkinsonian syndromes

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