Partial volume correction using structural-functional synergistic resolution recovery: comparison with geometric transfer matrix method

TY - JOUR

T1 - Partial volume correction using structural-functional synergistic resolution recovery

T2 - comparison with geometric transfer matrix method

AU - Kim, Euitae

AU - Shidahara, Miho

AU - Tsoumpas, Charalampos

AU - McGinnity, Colm J

AU - Kwon, Jun Soo

AU - Howes, Oliver D

AU - Turkheimer, Federico E

PY - 2013/6

Y1 - 2013/6

N2 - We validated the use of a novel image-based method for partial volume correction (PVC), structural-functional synergistic resolution recovery (SFS-RR) for the accurate quantification of dopamine synthesis capacity measured using [(18)F]DOPA positron emission tomography. The bias and reliability of SFS-RR were compared with the geometric transfer matrix (GTM) method. Both methodologies were applied to the parametric maps of [(18)F]DOPA utilization rates (ki(cer)). Validation was first performed by measuring repeatability on test-retest scans. The precision of the methodologies instead was quantified using simulated [(18)F]DOPA images. The sensitivity to the misspecification of the full-width-half-maximum (FWHM) of the scanner point-spread-function on both approaches was also assessed. In the in-vivo data, the ki(cer) was significantly increased by application of both PVC procedures while the reliability remained high (intraclass correlation coefficients >0.85). The variability was not significantly affected by either PVC approach (<10% variability in both cases). The corrected ki(cer) was significantly influenced by the FWHM applied in both the acquired and simulated data. This study shows that SFS-RR can effectively correct for partial volume effects to a comparable degree to GTM but with the added advantage that it enables voxelwise analyses, and that the FWHM used can affect the PVC result indicating the importance of accurately calibrating the FWHM used in the recovery model.

AB - We validated the use of a novel image-based method for partial volume correction (PVC), structural-functional synergistic resolution recovery (SFS-RR) for the accurate quantification of dopamine synthesis capacity measured using [(18)F]DOPA positron emission tomography. The bias and reliability of SFS-RR were compared with the geometric transfer matrix (GTM) method. Both methodologies were applied to the parametric maps of [(18)F]DOPA utilization rates (ki(cer)). Validation was first performed by measuring repeatability on test-retest scans. The precision of the methodologies instead was quantified using simulated [(18)F]DOPA images. The sensitivity to the misspecification of the full-width-half-maximum (FWHM) of the scanner point-spread-function on both approaches was also assessed. In the in-vivo data, the ki(cer) was significantly increased by application of both PVC procedures while the reliability remained high (intraclass correlation coefficients >0.85). The variability was not significantly affected by either PVC approach (<10% variability in both cases). The corrected ki(cer) was significantly influenced by the FWHM applied in both the acquired and simulated data. This study shows that SFS-RR can effectively correct for partial volume effects to a comparable degree to GTM but with the added advantage that it enables voxelwise analyses, and that the FWHM used can affect the PVC result indicating the importance of accurately calibrating the FWHM used in the recovery model.

KW - dopamine

KW - GTM

KW - partial volume correction

KW - partial volume effect

KW - positron emission tomography

KW - SFS-RR

KW - [F-18]DOPA

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - DOPAMINE SYNTHESIS CAPACITY

KW - PET

KW - BRAIN

KW - IMAGES

KW - IMPLEMENTATION

KW - PSYCHOSIS

U2 - 10.1038/jcbfm.2013.29

DO - 10.1038/jcbfm.2013.29

M3 - Article

C2 - 23486292

SN - 0271-678X

VL - 33

SP - 914

EP - 920

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

IS - 6

ER -