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Past year intimate partner violence perpetration among people with and without depression: an individual participant data (IPD) meta-mediation analysis.

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
JournalSocial Psychiatry and Psychiatric Epidemiology
Early online date29 Nov 2021
Accepted/In press1 Nov 2021
E-pub ahead of print29 Nov 2021

Bibliographical note

Funding Information: KRKS is funded by an NIHR Maudsley BRC PhD Studentship. This study represents independent research funded by the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. LMH and SL acknowledge that this paper represents independent research part-funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, King’s College London and the NIHR Applied Research Collaboration South London (NIHR ARC South London) at King’s College Hospital NHS Foundation Trust. SO, LMH, and HLF were supported by the UKRI Violence Abuse and Mental Health Network (ES/S004424/1). HLF was supported by the Economic and Social Research Council (ESRC) Centre for Society and Mental Health at King’s College London [ES/S012567/1]. LA is the Mental Health Leadership Fellow for the ESRC. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, the Department of Health and Social Care, the ESRC, or King’s College London. GFHM was supported by Health Research Council of New Zealand Programme Grant application [Grant16/600]. The E-Risk Study is funded by the Medical Research Council (UK MRC) [G1002190] and additional support was provided by the U.S National Institute of Child Health and Human Development (NICHD) grant [HD077482]. This research uses data from Add Health, a programme project directed by Kathleen Mullan Harris and designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris at the University of North Carolina at Chapel Hill, and funded by grant P01-HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 23 other federal agencies and foundations. Information on how to obtain the Add Health data files is available on the Add Health website ( ). No direct support was received from grant P01-HD31921 for this analysis. Publisher Copyright: © 2021, The Author(s).

King's Authors


Purpose: To investigate whether (1) depression is associated with increased risk of past year intimate partner violence (IPV) perpetration, disaggregated by sex, after controlling for potential confounders; (2) observed associations are mediated by alcohol misuse or past year IPV victimisation.

Methods: Systematic review and individual participant data (IPD) meta-mediation analysis of general population surveys of participants aged 16 years or older, that were conducted in a high-income country setting, and measured mental disorder and IPV perpetration in the last 12 months.

Results: Four datasets contributed to meta-mediation analyses, with a combined sample of 12,679 participants. Depression was associated with a 7.4% and 4.8% proportion increase of past year physical IPV perpetration among women and men respectively. We found no evidence of mediation by alcohol misuse. Among women, past year IPV victimisation mediated 45% of the total effect of depression on past year IPV perpetration. Past year severe IPV victimisation mediated 60% of the total effect of depression on past year severe IPV perpetration. We could not investigate IPV victimisation as a mediator among men due to perfect prediction.

Conclusions: Mental health services, criminal justice services, and domestic violence perpetrator programmes should be aware that depression is associated with increased risk of IPV perpetration. Interventions to reduce IPV victimisation might help prevent IPV perpetration by women. Data collection on mental disorder and IPV perpetration should be strengthened in future population-based surveys, with greater consistency of data collection across surveys, as only four studies were able to contribute to the meta-mediation analysis.

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