Abstract
Oral candidiasis remains one of the most common forms of Candida infections and occurs if the balance between host, Candida and microbiota is disturbed, e.g., by broad spectrum antibiotics or immunosuppression. In recent years, identification of fungal factors contributing to host cell damage and new insights into host defense mechanisms have significantly extended our understanding of the pathogenesis of oral candidiasis. In this review, we will provide an overview of the pathogenicity mechanisms during oral Candida infections and discuss some approaches by which this knowledge could be transferred into therapeutic approaches.
Original language | English |
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Pages (from-to) | 867-879 |
Number of pages | 13 |
Journal | Expert Review Of Anti-Infective Therapy |
Volume | 12 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2014 |
Keywords
- adhesion
- damage
- epithelial cells
- immunosuppression
- infection models
- innate immunity
- invasion
- EPITHELIAL-CELLS
- OROPHARYNGEAL CANDIDIASIS
- IN-VITRO
- MURINE MODEL
- TH17 CELLS
- STAPHYLOCOCCUS-AUREUS
- VAGINAL CANDIDIASIS
- ANTIFUNGAL DEFENSE
- FUNGAL-INFECTIONS
- BIOFILM FORMATION