Pathogenicity mechanisms and host response during oral Candida albicans infections

Betty Hebecker, Julian R. Naglik, Bernhard Hube, Ilse D. Jacobsen*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

83 Citations (Scopus)

Abstract

Oral candidiasis remains one of the most common forms of Candida infections and occurs if the balance between host, Candida and microbiota is disturbed, e.g., by broad spectrum antibiotics or immunosuppression. In recent years, identification of fungal factors contributing to host cell damage and new insights into host defense mechanisms have significantly extended our understanding of the pathogenesis of oral candidiasis. In this review, we will provide an overview of the pathogenicity mechanisms during oral Candida infections and discuss some approaches by which this knowledge could be transferred into therapeutic approaches.

Original languageEnglish
Pages (from-to)867-879
Number of pages13
JournalExpert Review Of Anti-Infective Therapy
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 2014

Keywords

  • adhesion
  • damage
  • epithelial cells
  • immunosuppression
  • infection models
  • innate immunity
  • invasion
  • EPITHELIAL-CELLS
  • OROPHARYNGEAL CANDIDIASIS
  • IN-VITRO
  • MURINE MODEL
  • TH17 CELLS
  • STAPHYLOCOCCUS-AUREUS
  • VAGINAL CANDIDIASIS
  • ANTIFUNGAL DEFENSE
  • FUNGAL-INFECTIONS
  • BIOFILM FORMATION

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