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Pathophysiology of AKI

Research output: Contribution to journalArticlepeer-review

Marlies Ostermann, Kathleen Liu

Original languageEnglish
JournalBailliere's Best Practice in Clinical Anaesthesiology
Early online date22 Sep 2017
Accepted/In press18 Sep 2017
E-pub ahead of print22 Sep 2017


King's Authors


Acute kidney injury (AKI) is common in the perioperative and intensive care setting. Although AKI is usually multifactorial, haemodynamic instability, sepsis and drug toxicity are commonly implicated. Independent of the exact aetiology, several different pathophysiologic processes occur simultaneously and in sequence, including endothelial dysfunction, alteration of the microcirculation, tubular injury, venous congestion and intrarenal inflammation. A multitude of different immune cells from within the kidney and the systemic circulation play a role in the development, maintenance and recovery phase of AKI. In this review we describe the common processes involved in AKI and their connections with particular emphasis on the perioperative and critical care setting.

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