Abstract
Purpose of review:
Here, we review the pathways of allorecognition and their potential relevance to the balance between regulatory and effector responses following transplantation.
Recent findings:
Transplantation between nonidentical members of the same species elicits an immune response that manifests as graft rejection or persistence. Presentation of foreign antigen to recipient T cells can occur via three nonmutually exclusive routes, the direct, indirect and semi-direct pathways. Allospecific T cells can have effector or regulatory functions, and the relative proportions of the two populations activated following alloantigen presentation are two of the factors that determine the clinical outcome. Regulatory T cells have been the subject of significant research, and there is now greater understanding of their recruitment and function in the context of allorecognition.
Summary:
A greater understanding of the mechanisms underlying allorecognition may be fundamental to appreciating how these different populations are recruited and could in turn inform novel strategies for immunodulation.
| Original language | English |
|---|---|
| Pages (from-to) | 438-444 |
| Number of pages | 7 |
| Journal | Current Opinion in Organ Transplantation |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2008 |
Keywords
- allorecognition
- direct
- human
- indirect
- mouse
- regulatory T cells
- semi-direct
- transplantation
- REGULATORY T-CELLS
- MHC CLASS-II
- RENAL-TRANSPLANT PATIENTS
- ANTIGEN-PRESENTING CELLS
- DENDRITIC CELLS
- INDIRECT RECOGNITION
- ALLOGRAFT-REJECTION
- IN-VIVO
- CUTTING EDGE
- INTRATRACHEAL DELIVERY