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Pathways to schizophrenia: the impact of environmental factors

Research output: Contribution to journalConference paper

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Pathways to schizophrenia: the impact of environmental factors. / Howes, O D; McDonald, C; Cannon, M; Arseneault, L; Boydell, J; Murray, R M.

In: International Journal of Neuropsychopharmacology , Vol. 7, No. SUPPL. 1, 03.2004, p. S7 - S13.

Research output: Contribution to journalConference paper

Harvard

Howes, OD, McDonald, C, Cannon, M, Arseneault, L, Boydell, J & Murray, RM 2004, 'Pathways to schizophrenia: the impact of environmental factors', International Journal of Neuropsychopharmacology , vol. 7, no. SUPPL. 1, pp. S7 - S13.

APA

Howes, O. D., McDonald, C., Cannon, M., Arseneault, L., Boydell, J., & Murray, R. M. (2004). Pathways to schizophrenia: the impact of environmental factors. International Journal of Neuropsychopharmacology , 7(SUPPL. 1), S7 - S13.

Vancouver

Howes OD, McDonald C, Cannon M, Arseneault L, Boydell J, Murray RM. Pathways to schizophrenia: the impact of environmental factors. International Journal of Neuropsychopharmacology . 2004 Mar;7(SUPPL. 1):S7 - S13.

Author

Howes, O D ; McDonald, C ; Cannon, M ; Arseneault, L ; Boydell, J ; Murray, R M. / Pathways to schizophrenia: the impact of environmental factors. In: International Journal of Neuropsychopharmacology . 2004 ; Vol. 7, No. SUPPL. 1. pp. S7 - S13.

Bibtex Download

@article{18018b3abc144cb8b6cc812d0ca7ac6d,
title = "Pathways to schizophrenia: the impact of environmental factors",
abstract = "Schizophrenia is an aetiologically complex disorder arising from the interaction of a range of factors acting at various stages of life. Schizophrenic individuals inherit genes that cause structural brain 'deviations' which may be compounded by early environmental insults. As a result some pre-schizophrenic children exhibit subtle developmental delays, cognitive problems, or poor interpersonal relationships. They are susceptible to dysregulation of dopamine, the final pathway leading to the onset of a psychotic illness. Dopamine dysregulation may arise through a process of sensitization, which, in animals, can be caused by repeated administration of dopamine-releasing drugs. It is clear that the same process occurs in humans, and that some individuals are particularly sensitive to the effects of such drugs for either genetic reasons or through early environmental damage. Stress has also been shown to induce dopamine release in animal studies, and epidemiological studies have demonstrated that social stresses can precipitate schizophrenia. Thus, stresses, such as drug use and social adversity, in adolescence or early adult life may propel the neurodevelopmentally impaired individual over a threshold into frank psychosis.",
author = "Howes, {O D} and C McDonald and M Cannon and L Arseneault and J Boydell and Murray, {R M}",
year = "2004",
month = mar,
language = "English",
volume = "7",
pages = "S7 -- S13",
journal = "International Journal of Neuropsychopharmacology ",
issn = "1461-1457",
publisher = "Oxford University Press",
number = "SUPPL. 1",
note = "2nd International Schizophrenia Forum ; Conference date: 01-01-2004",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Pathways to schizophrenia: the impact of environmental factors

AU - Howes, O D

AU - McDonald, C

AU - Cannon, M

AU - Arseneault, L

AU - Boydell, J

AU - Murray, R M

PY - 2004/3

Y1 - 2004/3

N2 - Schizophrenia is an aetiologically complex disorder arising from the interaction of a range of factors acting at various stages of life. Schizophrenic individuals inherit genes that cause structural brain 'deviations' which may be compounded by early environmental insults. As a result some pre-schizophrenic children exhibit subtle developmental delays, cognitive problems, or poor interpersonal relationships. They are susceptible to dysregulation of dopamine, the final pathway leading to the onset of a psychotic illness. Dopamine dysregulation may arise through a process of sensitization, which, in animals, can be caused by repeated administration of dopamine-releasing drugs. It is clear that the same process occurs in humans, and that some individuals are particularly sensitive to the effects of such drugs for either genetic reasons or through early environmental damage. Stress has also been shown to induce dopamine release in animal studies, and epidemiological studies have demonstrated that social stresses can precipitate schizophrenia. Thus, stresses, such as drug use and social adversity, in adolescence or early adult life may propel the neurodevelopmentally impaired individual over a threshold into frank psychosis.

AB - Schizophrenia is an aetiologically complex disorder arising from the interaction of a range of factors acting at various stages of life. Schizophrenic individuals inherit genes that cause structural brain 'deviations' which may be compounded by early environmental insults. As a result some pre-schizophrenic children exhibit subtle developmental delays, cognitive problems, or poor interpersonal relationships. They are susceptible to dysregulation of dopamine, the final pathway leading to the onset of a psychotic illness. Dopamine dysregulation may arise through a process of sensitization, which, in animals, can be caused by repeated administration of dopamine-releasing drugs. It is clear that the same process occurs in humans, and that some individuals are particularly sensitive to the effects of such drugs for either genetic reasons or through early environmental damage. Stress has also been shown to induce dopamine release in animal studies, and epidemiological studies have demonstrated that social stresses can precipitate schizophrenia. Thus, stresses, such as drug use and social adversity, in adolescence or early adult life may propel the neurodevelopmentally impaired individual over a threshold into frank psychosis.

UR - http://www.scopus.com/inward/record.url?scp=1842575680&partnerID=8YFLogxK

M3 - Conference paper

VL - 7

SP - S7 - S13

JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

SN - 1461-1457

IS - SUPPL. 1

T2 - 2nd International Schizophrenia Forum

Y2 - 1 January 2004

ER -

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