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Patient-specific modeling of atrial fibrosis increases the accuracy of sinus rhythm simulations and may explain maintenance of atrial fibrillation

Research output: Contribution to journalArticle

Martin W Krueger, Kawal S Rhode, Mark D O'Neill, C Aldo Rinaldi, Jaswinder Gill, Reza Razavi, Gunnar Seemann, Olaf Doessel

Original languageEnglish
Pages (from-to)324-328
Number of pages5
JournalJournal of Electrocardiology
Issue number3
PublishedMay 2014

King's Authors


Left atrial fibrosis is thought to contribute to the manifestation of atrial fibrillation (AF). Late Gadolinium enhancement (LGE) MRI has the potential to image regions of low perfusion, which can be related to fibrosis. We show that a simulation with a patient-specific model including left atrial regional fibrosis derived from LGE-MRI reproduces local activation in the left atrium more precisely than the regular simulation without fibrosis. AF simulations showed a spontaneous termination of the arrhythmia in the absence of fibrosis and a stable rotor center in the presence of fibrosis. The methodology may provide a tool for a deeper understanding of the mechanisms maintaining AF and eventually also for the planning of substrate-guided ablation procedures in the future.

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