Patterning of the mammalian cochlea

TY - JOUR

T1 - Patterning of the mammalian cochlea

AU - Cantos, R

AU - Cole, L K

AU - Acampora, D

AU - Simeone, A

AU - Wu, D K

PY - 2000/10/24

Y1 - 2000/10/24

N2 - The mammalian cochlea is sophisticated in its function and highly organized in its structure. Although the anatomy of this sense organ has been well documented, the molecular mechanisms underlying its development have remained elusive. Information generated from mutant and knockout mice in recent years has increased our understanding of cochlear development and physiology. This article discusses factors important for the development of the inner ear and summarizes cochlear phenotypes of mutant and knockout mice, particularly Otx and Otx2. We also present data on gross development of the mouse cochlea.

AB - The mammalian cochlea is sophisticated in its function and highly organized in its structure. Although the anatomy of this sense organ has been well documented, the molecular mechanisms underlying its development have remained elusive. Information generated from mutant and knockout mice in recent years has increased our understanding of cochlear development and physiology. This article discusses factors important for the development of the inner ear and summarizes cochlear phenotypes of mutant and knockout mice, particularly Otx and Otx2. We also present data on gross development of the mouse cochlea.

UR - http://www.scopus.com/inward/record.url?scp=0034710964&partnerID=8YFLogxK

M3 - Conference paper

SN - 1091-6490

VL - 97

SP - 11707

EP - 11713

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 22

T2 - National Academy of Sciences Colloquium on Auditory Neuroscience - Development, Transduction, and Integration

Y2 - 1 January 2000

ER -