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Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance

Research output: Contribution to journalReview articlepeer-review

Kirsty Logan, George Du Toit, Mattia Giovannini, Victor Turcanu, Gideon Lack

Original languageEnglish
Pages (from-to)511-528
Number of pages18
JournalAnnual Review of Cell and Developmental Biology
Published6 Oct 2020

King's Authors


Pediatric allergic disease is a significant health concern worldwide, and the prevalence of childhood eczema, asthma, allergic rhinitis, and food allergy continues to increase. Evidence to support specific interventions for the prevention of eczema, asthma, and allergic rhinitis is limited, and no consensus on prevention strategies has been reached. Randomized controlled trials investigating the prevention of food allergy via oral tolerance induction and the early introduction of allergenic foods have been successful in reducing peanut and egg allergy prevalence. Infant weaning guidelines in the United Sates were recently amended to actively encourage the introduction of peanut for prevention of peanut allergy.

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