Peptide immunotherapy for type 1 diabetes-clinical advances

TY - JOUR

T1 - Peptide immunotherapy for type 1 diabetes-clinical advances

AU - Smith, Emma L.

AU - Peakman, Mark

PY - 2018/2/28

Y1 - 2018/2/28

N2 - Autoimmune and allergic diseases occur when an individual mounts an inappropriate immune response to a self-antigen or an innocuous environmental antigen. This triggers a pathogenic T-cell response resulting in damage to specific tissues and organs. In type 1 diabetes (T1D), this manifests as destruction of the insulin-secreting β cells, resulting in a life-long dependency on recombinant insulin. Modulation of the pathogenic T-cell response with antigen-specific peptide immunotherapy offers the potential to restore the immune homeostasis and prevent further tissue destruction. Recent clinical advances with peptide therapy approaches in both T1D and other diseases are beginning to show encouraging results. New technologies targeting the peptides to specific cell types are also moving from pre-clinical development to the clinic. While many challenges remain in clinical development, not least selection of the optimal dose and dosing frequency, this is clearly becoming a very active field of drug development.

AB - Autoimmune and allergic diseases occur when an individual mounts an inappropriate immune response to a self-antigen or an innocuous environmental antigen. This triggers a pathogenic T-cell response resulting in damage to specific tissues and organs. In type 1 diabetes (T1D), this manifests as destruction of the insulin-secreting β cells, resulting in a life-long dependency on recombinant insulin. Modulation of the pathogenic T-cell response with antigen-specific peptide immunotherapy offers the potential to restore the immune homeostasis and prevent further tissue destruction. Recent clinical advances with peptide therapy approaches in both T1D and other diseases are beginning to show encouraging results. New technologies targeting the peptides to specific cell types are also moving from pre-clinical development to the clinic. While many challenges remain in clinical development, not least selection of the optimal dose and dosing frequency, this is clearly becoming a very active field of drug development.

KW - Antigen specific

KW - Autoimmunity

KW - Peptide immunotherapy

KW - Tolerance

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85042701697&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2018.00392

DO - 10.3389/fimmu.2018.00392

M3 - Short survey

AN - SCOPUS:85042701697

SN - 1664-3224

VL - 9

JO - Frontiers in Immunology

JF - Frontiers in Immunology

IS - FEB

M1 - 392

ER -