Performance Evaluation of an MRI-Compatible Pre-Clinical PET System Using Long Optical Fibers

Jane E. Mackewn; Philip Halsted; Geoffrey Charles-Edwards; Richard Page; John J. Totman; Kavitha Sunassee; Daniel Strul; William A. Hallett; Maite Jauregui-Osoro; Peter Liepins; Steven C. R. Williams; Tobias Schaeffter; Stephen F. Keevil; Paul K. Marsden

doi:10.1109/TNS.2010.2044891

Performance Evaluation of an MRI-Compatible Pre-Clinical PET System Using Long Optical Fibers

Jane E. Mackewn, Philip Halsted, Geoffrey Charles-Edwards, Richard Page, John J. Totman, Kavitha Sunassee, Daniel Strul, William A. Hallett, Maite Jauregui-Osoro, Peter Liepins, Steven C. R. Williams, Tobias Schaeffter, Stephen F. Keevil, Paul K. Marsden

King's College London

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

We have designed and constructed an MR-compatible PET system for fully simultaneous PET/MR studies of small animals. The scanner uses long optical fibers to distance the magnetic field sensitive PET PMTs from the high magnetic field at the center of an MR scanner. It is a single slice system with an inner diameter of 7 cm. A full evaluation of the performance of the PET system and the results of an MR compatibility assessment in a Philips Achieva whole body 3 T MRI scanner are presented. The reconstructed resolution of the PET scanner is 1.5 mm at the center falling to 2.5 mm at the edge of the field of view; the system sensitivity is 0.95%; the count rate is linear up to an activity of 6 MBq (similar to 4 kcps) and the scatter fraction is 42% which can be reduced to 26% using MR-compatible gamma shields. Simultaneous PET/MR images of phantoms and a mouse have been acquired. The system is highly MR compatible, as demonstrated here, showing no degradation in performance of either the MR or PET system in the presence of the other modality. The system will be used to demonstrate novel pre-clinical applications of simultaneous PET/MR.

Original language	English
Article number	5485148
Pages (from-to)	1052 - 1062
Number of pages	11
Journal	IEEE Transactions on Nuclear Science
Volume	57
Issue number	3
DOIs	https://doi.org/10.1109/TNS.2010.2044891
Publication status	Published - Jun 2010

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Mackewn, J. E., Halsted, P., Charles-Edwards, G., Page, R., Totman, J. J., Sunassee, K., Strul, D., Hallett, W. A., Jauregui-Osoro, M., Liepins, P., Williams, S. C. R., Schaeffter, T., Keevil, S. F., & Marsden, P. K. (2010). Performance Evaluation of an MRI-Compatible Pre-Clinical PET System Using Long Optical Fibers. IEEE Transactions on Nuclear Science, 57(3), 1052 - 1062. Article 5485148. https://doi.org/10.1109/TNS.2010.2044891

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title = "Performance Evaluation of an MRI-Compatible Pre-Clinical PET System Using Long Optical Fibers",

abstract = "We have designed and constructed an MR-compatible PET system for fully simultaneous PET/MR studies of small animals. The scanner uses long optical fibers to distance the magnetic field sensitive PET PMTs from the high magnetic field at the center of an MR scanner. It is a single slice system with an inner diameter of 7 cm. A full evaluation of the performance of the PET system and the results of an MR compatibility assessment in a Philips Achieva whole body 3 T MRI scanner are presented. The reconstructed resolution of the PET scanner is 1.5 mm at the center falling to 2.5 mm at the edge of the field of view; the system sensitivity is 0.95%; the count rate is linear up to an activity of 6 MBq (similar to 4 kcps) and the scatter fraction is 42% which can be reduced to 26% using MR-compatible gamma shields. Simultaneous PET/MR images of phantoms and a mouse have been acquired. The system is highly MR compatible, as demonstrated here, showing no degradation in performance of either the MR or PET system in the presence of the other modality. The system will be used to demonstrate novel pre-clinical applications of simultaneous PET/MR.",

author = "Mackewn, {Jane E.} and Philip Halsted and Geoffrey Charles-Edwards and Richard Page and Totman, {John J.} and Kavitha Sunassee and Daniel Strul and Hallett, {William A.} and Maite Jauregui-Osoro and Peter Liepins and Williams, {Steven C. R.} and Tobias Schaeffter and Keevil, {Stephen F.} and Marsden, {Paul K.}",

year = "2010",

month = jun,

doi = "10.1109/TNS.2010.2044891",

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journal = "IEEE Transactions on Nuclear Science",

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Mackewn, JE, Halsted, P, Charles-Edwards, G, Page, R, Totman, JJ, Sunassee, K , Strul, D, Hallett, WA, Jauregui-Osoro, M, Liepins, P, Williams, SCR , Schaeffter, T , Keevil, SF & Marsden, PK 2010, 'Performance Evaluation of an MRI-Compatible Pre-Clinical PET System Using Long Optical Fibers', IEEE Transactions on Nuclear Science, vol. 57, no. 3, 5485148, pp. 1052 - 1062. https://doi.org/10.1109/TNS.2010.2044891

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AU - Mackewn, Jane E.

AU - Halsted, Philip

AU - Charles-Edwards, Geoffrey

AU - Page, Richard

AU - Totman, John J.

AU - Sunassee, Kavitha

AU - Strul, Daniel

AU - Hallett, William A.

AU - Jauregui-Osoro, Maite

AU - Liepins, Peter

AU - Williams, Steven C. R.

AU - Schaeffter, Tobias

AU - Keevil, Stephen F.

AU - Marsden, Paul K.

PY - 2010/6

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N2 - We have designed and constructed an MR-compatible PET system for fully simultaneous PET/MR studies of small animals. The scanner uses long optical fibers to distance the magnetic field sensitive PET PMTs from the high magnetic field at the center of an MR scanner. It is a single slice system with an inner diameter of 7 cm. A full evaluation of the performance of the PET system and the results of an MR compatibility assessment in a Philips Achieva whole body 3 T MRI scanner are presented. The reconstructed resolution of the PET scanner is 1.5 mm at the center falling to 2.5 mm at the edge of the field of view; the system sensitivity is 0.95%; the count rate is linear up to an activity of 6 MBq (similar to 4 kcps) and the scatter fraction is 42% which can be reduced to 26% using MR-compatible gamma shields. Simultaneous PET/MR images of phantoms and a mouse have been acquired. The system is highly MR compatible, as demonstrated here, showing no degradation in performance of either the MR or PET system in the presence of the other modality. The system will be used to demonstrate novel pre-clinical applications of simultaneous PET/MR.

AB - We have designed and constructed an MR-compatible PET system for fully simultaneous PET/MR studies of small animals. The scanner uses long optical fibers to distance the magnetic field sensitive PET PMTs from the high magnetic field at the center of an MR scanner. It is a single slice system with an inner diameter of 7 cm. A full evaluation of the performance of the PET system and the results of an MR compatibility assessment in a Philips Achieva whole body 3 T MRI scanner are presented. The reconstructed resolution of the PET scanner is 1.5 mm at the center falling to 2.5 mm at the edge of the field of view; the system sensitivity is 0.95%; the count rate is linear up to an activity of 6 MBq (similar to 4 kcps) and the scatter fraction is 42% which can be reduced to 26% using MR-compatible gamma shields. Simultaneous PET/MR images of phantoms and a mouse have been acquired. The system is highly MR compatible, as demonstrated here, showing no degradation in performance of either the MR or PET system in the presence of the other modality. The system will be used to demonstrate novel pre-clinical applications of simultaneous PET/MR.

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DO - 10.1109/TNS.2010.2044891

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SP - 1052

EP - 1062

JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

IS - 3

M1 - 5485148

ER -

Performance Evaluation of an MRI-Compatible Pre-Clinical PET System Using Long Optical Fibers

Abstract

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