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Perinatal brain damage: Mechanisms and neuroprotective strategies

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)465-483
Number of pages19
JournalJournal of the Indian Institute of Science
Issue number4
Publication statusPublished - 1 Oct 2012

King's Authors


Injury to the perinatal brain is a leading cause of childhood mortality and lifelong disability. Cerebral palsy and cognitive impairment are usually related to periventricular white matter damage, which is seen chiefly in babies born before 32 weeks' gestational age, and to corticosubcortical lesions, which occur mainly in full term infants. Perinatal brain lesions remain largely unpreventable and untreatable despite recent improvements in neonatal care. However, partial neuroprotective efficacy has been proven using magnesium sulfate in preterm newborns and hypothermia in term newborns. Improved understanding of the pathophysiological mechanisms involved in perinatal brain lesions helps to identify potential targets for neuroprotective interventions, as discussed in this review.

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