Perinatal brain damage: Mechanisms and neuroprotective strategies

Pierre Gressens; Henrik Hagberg

Perinatal brain damage: Mechanisms and neuroprotective strategies

Pierre Gressens^*
, Henrik Hagberg

^*Corresponding author for this work

INSERM
Université Paris Diderot
University of Paris VII - Denis Diderot University
King's College London
Perinatal Center
University of Gothenburg

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Injury to the perinatal brain is a leading cause of childhood mortality and lifelong disability. Cerebral palsy and cognitive impairment are usually related to periventricular white matter damage, which is seen chiefly in babies born before 32 weeks' gestational age, and to corticosubcortical lesions, which occur mainly in full term infants. Perinatal brain lesions remain largely unpreventable and untreatable despite recent improvements in neonatal care. However, partial neuroprotective efficacy has been proven using magnesium sulfate in preterm newborns and hypothermia in term newborns. Improved understanding of the pathophysiological mechanisms involved in perinatal brain lesions helps to identify potential targets for neuroprotective interventions, as discussed in this review.

Original language	English
Pages (from-to)	465-483
Number of pages	19
Journal	Journal of the Indian Institute of Science
Volume	92
Issue number	4
Publication status	Published - 1 Oct 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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abstract = "Injury to the perinatal brain is a leading cause of childhood mortality and lifelong disability. Cerebral palsy and cognitive impairment are usually related to periventricular white matter damage, which is seen chiefly in babies born before 32 weeks' gestational age, and to corticosubcortical lesions, which occur mainly in full term infants. Perinatal brain lesions remain largely unpreventable and untreatable despite recent improvements in neonatal care. However, partial neuroprotective efficacy has been proven using magnesium sulfate in preterm newborns and hypothermia in term newborns. Improved understanding of the pathophysiological mechanisms involved in perinatal brain lesions helps to identify potential targets for neuroprotective interventions, as discussed in this review.",

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AU - Hagberg, Henrik

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N2 - Injury to the perinatal brain is a leading cause of childhood mortality and lifelong disability. Cerebral palsy and cognitive impairment are usually related to periventricular white matter damage, which is seen chiefly in babies born before 32 weeks' gestational age, and to corticosubcortical lesions, which occur mainly in full term infants. Perinatal brain lesions remain largely unpreventable and untreatable despite recent improvements in neonatal care. However, partial neuroprotective efficacy has been proven using magnesium sulfate in preterm newborns and hypothermia in term newborns. Improved understanding of the pathophysiological mechanisms involved in perinatal brain lesions helps to identify potential targets for neuroprotective interventions, as discussed in this review.

AB - Injury to the perinatal brain is a leading cause of childhood mortality and lifelong disability. Cerebral palsy and cognitive impairment are usually related to periventricular white matter damage, which is seen chiefly in babies born before 32 weeks' gestational age, and to corticosubcortical lesions, which occur mainly in full term infants. Perinatal brain lesions remain largely unpreventable and untreatable despite recent improvements in neonatal care. However, partial neuroprotective efficacy has been proven using magnesium sulfate in preterm newborns and hypothermia in term newborns. Improved understanding of the pathophysiological mechanisms involved in perinatal brain lesions helps to identify potential targets for neuroprotective interventions, as discussed in this review.

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M3 - Review article

AN - SCOPUS:84876265065

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JO - Journal of the Indian Institute of Science

JF - Journal of the Indian Institute of Science

IS - 4

ER -

Perinatal brain damage: Mechanisms and neuroprotective strategies

Abstract

UN SDGs

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