Periodontal health and disease: The contribution of genetics

TY - JOUR

T1 - Periodontal health and disease

T2 - The contribution of genetics

AU - Shaddox, Luciana Macchion

AU - Morford, Lorri Ann

AU - Nibali, Luigi

PY - 2021/2

Y1 - 2021/2

N2 - Periodontitis is an infectious, inflammatory disease that is associated with a complex interplay between specific bacteria, host response, and environmental factors. Because of its high degree of familial aggregation, specifically for the more aggressive forms of the disease, genetics factors have been implicated in disease pathogenesis for several decades. This review provides an overview of what we currently know regarding the genetic and epigenetic contributions to periodontal disease and discusses future opportunities in the field.

AB - Periodontitis is an infectious, inflammatory disease that is associated with a complex interplay between specific bacteria, host response, and environmental factors. Because of its high degree of familial aggregation, specifically for the more aggressive forms of the disease, genetics factors have been implicated in disease pathogenesis for several decades. This review provides an overview of what we currently know regarding the genetic and epigenetic contributions to periodontal disease and discusses future opportunities in the field.

KW - epigenetics

KW - genetic variation

KW - microbiology

KW - periodontitis/periodontal disease

KW - single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=85096717246&partnerID=8YFLogxK

U2 - 10.1111/prd.12357

DO - 10.1111/prd.12357

M3 - Review article

AN - SCOPUS:85096717246

SN - 0906-6713

VL - 85

SP - 161

EP - 181

JO - PERIODONTOLOGY 2000

JF - PERIODONTOLOGY 2000

IS - 1

ER -