Perioperative Therapies: Enhancing the Impact of Cancer Surgery with Repurposed Drugs

TY - JOUR

T1 - Perioperative Therapies

T2 - Enhancing the Impact of Cancer Surgery with Repurposed Drugs

AU - Pantziarka, Pan

AU - Bouche, Gauthier

AU - Sullivan, Richard

AU - Ilbawi, André M.

AU - Dare, Anna

AU - Meheus, Lydie

PY - 2017/9/7

Y1 - 2017/9/7

N2 - Surgical resection remains the major modality for modern curative treatment for solid tumours. However, post-surgical recurrence, even following clear-margin resection and adjuvant treatment, remains common in many types of cancer. Reducing recurrence rates, therefore, offers the potential to increase cure rates and increase overall survival. Perioperative therapies, simple interventions during the perioperative period, are designed to address some of the factors which influence post-surgical recurrence. A range of perioperative therapies are introduced and the rationale for further clinical investigation outlined.

AB - Surgical resection remains the major modality for modern curative treatment for solid tumours. However, post-surgical recurrence, even following clear-margin resection and adjuvant treatment, remains common in many types of cancer. Reducing recurrence rates, therefore, offers the potential to increase cure rates and increase overall survival. Perioperative therapies, simple interventions during the perioperative period, are designed to address some of the factors which influence post-surgical recurrence. A range of perioperative therapies are introduced and the rationale for further clinical investigation outlined.

KW - Perioperative period

KW - surgical resection

KW - metastases

KW - cancer recurrence

KW - drug repurposing

U2 - 10.1016/j.ejso.2017.08.010

DO - 10.1016/j.ejso.2017.08.010

M3 - Article

SN - 0748-7983

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

ER -