Research output: Contribution to journal › Article › peer-review
Sarah-Naomi James, Celeste H M Cheung, Anna-Sophie Rommel, Gráinne McLoughlin, Daniel Brandeis, Tobias Banaschewski, Philip Asherson, Jonna Kuntsi
Original language | English |
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Journal | Journal of Attention Disorders |
Early online date | 31 Mar 2017 |
DOIs | |
E-pub ahead of print | 31 Mar 2017 |
Published | 31 May 2017 |
Peripheral Hypoarousal but Not_JAMES_Publishedonline31March2017_GOLD VoR (CC-BY)
Peripheral_Hypoarousal_but_Not_JAMES_Publishedonline31March2017_GOLD_VoR_CC_BY_.pdf, 363 KB, application/pdf
Uploaded date:17 May 2017
Version:Final published version
Licence:CC BY
OBJECTIVE: This study investigates whether impairments associated with persistent ADHD-impaired attention allocation (P3 amplitude), peripheral hypoarousal (skin conductance level [SCL]), and adjustment in preparatory state (contingent negative variation [CNV])-reflect enduring deficits unrelated to ADHD outcome or are markers of ADHD remission.
METHOD: Young people with childhood ADHD (73 persisters and 18 remitters) and 144 controls were compared on neurophysiological measures during two conditions (baseline and fast-incentive) of a four-choice reaction time task.
RESULTS: ADHD remitters differed from persisters, and were indistinguishable from controls, on baseline P3 amplitude and fast-incentive CNV amplitude ( p ≤ .05). ADHD remitters differed from controls ( p ≤ .01), and were indistinguishable from persisters ( p > .05), on baseline SCL.
CONCLUSION: Preparation-vigilance measures were markers of ADHD remission, confirming previous findings with other measures. Yet, SCL-measured peripheral hypoarousal emerges as an enduring deficit unrelated to ADHD improvement. Future studies should explore potential compensatory mechanisms that enable efficient preparation-vigilance processes in ADHD remitters.
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