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Peripheral mechanisms II: the pharmacology of peripherally active antitussive drugs

Research output: Chapter in Book/Report/Conference proceedingChapter

D Spina, I McFadzean, F K R Bertram, C P Page

Original languageEnglish
Title of host publicationPharmacology and Therapeutics of Cough
PublisherSpringer
Pages155-186
Number of pages32
Volume187
ISBN (Electronic)9783540798422
ISBN (Print)9783540798415
DOIs
Publication statusPublished - 2009

Publication series

NameHandbook of Experimental Pharmacology
PublisherSpringer

King's Authors

Abstract

Cough is an indispensable defensive reflex. Although generally beneficial, it is also a common symptom of diseases such as asthma, chronic obstructive pulmonary disease, upper respiratory tract infections, idiopathic pulmonary fibrosis and lung cancer. Cough remains a major unmet medical need and although the centrally acting opioids have remained the antitussive of choice for decades, they have many unwanted side effects. However, new research into the behaviour of airway sensory nerves has provided greater insight into the mechanisms of cough and new avenues for the discovery of novel non-opioid antitussive drugs. In this review, the pathophysiological mechanisms of cough and the development of novel antitussive drugs are reviewed.

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