TY - JOUR
T1 - Peripheral oxytocin and vasopressin
T2 - Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis
AU - Rutigliano, Grazia
AU - Rocchetti, Matteo
AU - Paloyelis, Yannis
AU - Gilleen, James
AU - Sardella, Alberto
AU - Cappucciati, Marco
AU - Palombini, Erika
AU - Dell'Osso, Liliana
AU - Caverzasi, Edgardo
AU - Politi, Pierluigi
AU - McGuire, Philip
AU - Fusar-Poli, Paolo
PY - 2016/7/30
Y1 - 2016/7/30
N2 - A large array of studies have investigated peripheral oxytocin (OT) and vasopressin (ADH) as potential biomarkers of psychiatric disorders, with highly conflicting and heterogenous findings. We searched Web of KnowledgeSM and Scopus® for English original articles investigating OT and/or ADH levels in different biological fluids (plasma/serum, saliva, urine and cerebrospinal fluid) across several psychiatric disorders. Sixty-four studies were included. We conducted 19 preliminary meta-analyses addressing OT alterations in plasma/serum, saliva, urine and cerebrospinal fluid of 7 psychiatric disorders and ADH alterations in plasma/serum, saliva, urine and cerebrospinal fluid of 6 psychiatric disorders compared to controls. Hedge's g was used as effect size measure, together with heterogeneity analyses, test of publication biases and quality control. None of them (except serum OT in anorexia nervosa) revealed significant differences. There is no convincing evidence that peripheral ADH or OT might be reliable biomarkers in psychiatric disorders. However, the lack of significant results was associated with high methodological heterogeneity, low quality of the studies, small sample size, and scarce reliability of the methods used in previous studies, which need to be validated and standardized.
AB - A large array of studies have investigated peripheral oxytocin (OT) and vasopressin (ADH) as potential biomarkers of psychiatric disorders, with highly conflicting and heterogenous findings. We searched Web of KnowledgeSM and Scopus® for English original articles investigating OT and/or ADH levels in different biological fluids (plasma/serum, saliva, urine and cerebrospinal fluid) across several psychiatric disorders. Sixty-four studies were included. We conducted 19 preliminary meta-analyses addressing OT alterations in plasma/serum, saliva, urine and cerebrospinal fluid of 7 psychiatric disorders and ADH alterations in plasma/serum, saliva, urine and cerebrospinal fluid of 6 psychiatric disorders compared to controls. Hedge's g was used as effect size measure, together with heterogeneity analyses, test of publication biases and quality control. None of them (except serum OT in anorexia nervosa) revealed significant differences. There is no convincing evidence that peripheral ADH or OT might be reliable biomarkers in psychiatric disorders. However, the lack of significant results was associated with high methodological heterogeneity, low quality of the studies, small sample size, and scarce reliability of the methods used in previous studies, which need to be validated and standardized.
KW - Anorexia nervosa
KW - Autism spectrum disorder
KW - Bipolar disorder
KW - Bulimia nervosa
KW - Major depressive disorder
KW - Obsessive-compulsive disorder
KW - Psychosis
UR - http://www.scopus.com/inward/record.url?scp=84966638761&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2016.04.117
DO - 10.1016/j.psychres.2016.04.117
M3 - Article
AN - SCOPUS:84966638761
SN - 0165-1781
VL - 241
SP - 207
EP - 220
JO - Psychiatry Research
JF - Psychiatry Research
ER -
