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Peripheral signatures of the clusterin-DKK neurotoxicity pathway as potential blood-based biomarkers

Research output: Contribution to journalMeeting abstract

Simon Lovestone, Martina Sattlecker, Abhishek Dixit, Steven Kiddle, Rufina Leung, Chantal Bazenet, Megan Pritchard, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Alex Stewart, Steven Williams, Sally Nelson, Richard Dobson

Original languageUndefined/Unknown
Article numberP4-351
Pages (from-to)P860
Number of pages1
JournalAlzheimer's Dementia: The Journal of the Alzheimer's Association
Volume9
Issue number4 Suppl
DOIs
Published1 Jul 2013

King's Authors

Abstract

Clusterin is both a genetic risk factor and a potential biomarker for AD. Its role in disease however is uncertain; as a pleiotropic protein it might plausibly be involved in lipid metabolism, in innate immunity or in amyloid trafficking. Clusterin is also part of the regulation of cell survival and we recently showed that Abeta induces changes in the cellular distribution of clusterin and this in turn induces DKK1 expression and a pathway mediating neurotoxicity. An expression signature indicative of this pathway is present in brain of animals with amyloidopathy but not tauopathy and in brains of people with AD but not FTD.

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