Personalised biophysical model to optimize left ventricle pacing location for Cardiac Resynchronisation Therapy over time

Angela Lee; Manav Sohal; Jonathan Behar; Simon Claridge; Anoop Shetty; Thomas Jackson; Eoin Hyde; Gernot Plank; Reza Razavi; Pablo Lamata; Christopher Aldo Rinaldi; Steven Niederer

Personalised biophysical model to optimize left ventricle pacing location for Cardiac Resynchronisation Therapy over time

Angela Lee^*, Manav Sohal, Jonathan Behar, Simon Claridge, Anoop Shetty, Thomas Jackson, Eoin Hyde, Gernot Plank, Reza Razavi, Pablo Lamata, Christopher Aldo Rinaldi, Steven Niederer

^*Corresponding author for this work

Medical University of Graz

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

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Abstract

Cardiac Resynchronisation Therapy (CRT) causes changes in cardiac anatomy, electrophysiology and mechanics of the heart after 3-6 months of treatment. Multi-pole pacing (MPP) and multi-vein pacing (MVP) are new technologies that offer the ability to change the location of the pacing site post implant, however, the long term benefits of shifting the left ventricle (LV) pacing site are still uncertain. A personalised biophysical electromechanical model of a patient's heart was developed from MRI, echocardiogram, ECG and pressure catheter recordings, before and after sustained CRT treatment. Simulations of biventricular pacing of the heart were performed for 49 pacing sites across the LV free wall, in the model of the patient prior to- and after sustained pacing. The optimal region for LV pacing was determined by the acute haemodynamic response (AHR). After sustained CRT treatment the heart remodels and the models predict that the optimal region for pacing the LV would expand by 46% after this remodeling. The expansion in the optimal LV pacing region after remodeling predicts that if LV lead location was placed within the optimal region prior to CRT treatment, it will remain within the optimal region after sustained pacing.

Original language	English
Title of host publication	Computing in Cardiology
Publisher	IEEE Computer Society Press
Pages	757-759
Number of pages	3
Volume	43
ISBN (Print)	9781509008964
Publication status	Published - 1 Mar 2017
Event	43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada Duration: 11 Sept 2016 → 14 Sept 2016

Conference

Conference	43rd Computing in Cardiology Conference, CinC 2016
Country/Territory	Canada
City	Vancouver
Period	11/09/2016 → 14/09/2016

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Lee, A., Sohal, M., Behar, J., Claridge, S., Shetty, A., Jackson, T., Hyde, E., Plank, G., Razavi, R., Lamata, P., Rinaldi, C. A., & Niederer, S. (2017). Personalised biophysical model to optimize left ventricle pacing location for Cardiac Resynchronisation Therapy over time. In Computing in Cardiology (Vol. 43, pp. 757-759). Article 7868853 IEEE Computer Society Press.

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title = "Personalised biophysical model to optimize left ventricle pacing location for Cardiac Resynchronisation Therapy over time",

abstract = "Cardiac Resynchronisation Therapy (CRT) causes changes in cardiac anatomy, electrophysiology and mechanics of the heart after 3-6 months of treatment. Multi-pole pacing (MPP) and multi-vein pacing (MVP) are new technologies that offer the ability to change the location of the pacing site post implant, however, the long term benefits of shifting the left ventricle (LV) pacing site are still uncertain. A personalised biophysical electromechanical model of a patient's heart was developed from MRI, echocardiogram, ECG and pressure catheter recordings, before and after sustained CRT treatment. Simulations of biventricular pacing of the heart were performed for 49 pacing sites across the LV free wall, in the model of the patient prior to- and after sustained pacing. The optimal region for LV pacing was determined by the acute haemodynamic response (AHR). After sustained CRT treatment the heart remodels and the models predict that the optimal region for pacing the LV would expand by 46% after this remodeling. The expansion in the optimal LV pacing region after remodeling predicts that if LV lead location was placed within the optimal region prior to CRT treatment, it will remain within the optimal region after sustained pacing.",

author = "Angela Lee and Manav Sohal and Jonathan Behar and Simon Claridge and Anoop Shetty and Thomas Jackson and Eoin Hyde and Gernot Plank and Reza Razavi and Pablo Lamata and Rinaldi, {Christopher Aldo} and Steven Niederer",

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volume = "43",

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Lee, A , Sohal, M , Behar, J , Claridge, S , Shetty, A , Jackson, T , Hyde, E, Plank, G, Razavi, R , Lamata, P , Rinaldi, CA & Niederer, S 2017, Personalised biophysical model to optimize left ventricle pacing location for Cardiac Resynchronisation Therapy over time. in Computing in Cardiology. vol. 43, 7868853, IEEE Computer Society Press, pp. 757-759, 43rd Computing in Cardiology Conference, CinC 2016, Vancouver, Canada, 11/09/2016.

TY - CHAP

T1 - Personalised biophysical model to optimize left ventricle pacing location for Cardiac Resynchronisation Therapy over time

AU - Lee, Angela

AU - Sohal, Manav

AU - Behar, Jonathan

AU - Claridge, Simon

AU - Shetty, Anoop

AU - Jackson, Thomas

AU - Hyde, Eoin

AU - Plank, Gernot

AU - Razavi, Reza

AU - Lamata, Pablo

AU - Rinaldi, Christopher Aldo

AU - Niederer, Steven

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Cardiac Resynchronisation Therapy (CRT) causes changes in cardiac anatomy, electrophysiology and mechanics of the heart after 3-6 months of treatment. Multi-pole pacing (MPP) and multi-vein pacing (MVP) are new technologies that offer the ability to change the location of the pacing site post implant, however, the long term benefits of shifting the left ventricle (LV) pacing site are still uncertain. A personalised biophysical electromechanical model of a patient's heart was developed from MRI, echocardiogram, ECG and pressure catheter recordings, before and after sustained CRT treatment. Simulations of biventricular pacing of the heart were performed for 49 pacing sites across the LV free wall, in the model of the patient prior to- and after sustained pacing. The optimal region for LV pacing was determined by the acute haemodynamic response (AHR). After sustained CRT treatment the heart remodels and the models predict that the optimal region for pacing the LV would expand by 46% after this remodeling. The expansion in the optimal LV pacing region after remodeling predicts that if LV lead location was placed within the optimal region prior to CRT treatment, it will remain within the optimal region after sustained pacing.

AB - Cardiac Resynchronisation Therapy (CRT) causes changes in cardiac anatomy, electrophysiology and mechanics of the heart after 3-6 months of treatment. Multi-pole pacing (MPP) and multi-vein pacing (MVP) are new technologies that offer the ability to change the location of the pacing site post implant, however, the long term benefits of shifting the left ventricle (LV) pacing site are still uncertain. A personalised biophysical electromechanical model of a patient's heart was developed from MRI, echocardiogram, ECG and pressure catheter recordings, before and after sustained CRT treatment. Simulations of biventricular pacing of the heart were performed for 49 pacing sites across the LV free wall, in the model of the patient prior to- and after sustained pacing. The optimal region for LV pacing was determined by the acute haemodynamic response (AHR). After sustained CRT treatment the heart remodels and the models predict that the optimal region for pacing the LV would expand by 46% after this remodeling. The expansion in the optimal LV pacing region after remodeling predicts that if LV lead location was placed within the optimal region prior to CRT treatment, it will remain within the optimal region after sustained pacing.

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M3 - Conference paper

AN - SCOPUS:85016099168

SN - 9781509008964

VL - 43

SP - 757

EP - 759

BT - Computing in Cardiology

PB - IEEE Computer Society Press

T2 - 43rd Computing in Cardiology Conference, CinC 2016

Y2 - 11 September 2016 through 14 September 2016

ER -

Personalised biophysical model to optimize left ventricle pacing location for Cardiac Resynchronisation Therapy over time

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