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Personalised biophysical model to optimize left ventricle pacing location for Cardiac Resynchronisation Therapy over time

Research output: Chapter in Book/Report/Conference proceedingConference paper

Original languageEnglish
Title of host publicationComputing in Cardiology
PublisherIEEE Computer Society Press
Number of pages3
ISBN (Print)9781509008964
Publication statusPublished - 1 Mar 2017
Event43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada
Duration: 11 Sep 201614 Sep 2016


Conference43rd Computing in Cardiology Conference, CinC 2016


  • CinC_AngelaLee_v2

    CinC_AngelaLee_v2.pdf, 386 KB, application/pdf


    Submitted manuscript

King's Authors


Cardiac Resynchronisation Therapy (CRT) causes changes in cardiac anatomy, electrophysiology and mechanics of the heart after 3-6 months of treatment. Multi-pole pacing (MPP) and multi-vein pacing (MVP) are new technologies that offer the ability to change the location of the pacing site post implant, however, the long term benefits of shifting the left ventricle (LV) pacing site are still uncertain. A personalised biophysical electromechanical model of a patient's heart was developed from MRI, echocardiogram, ECG and pressure catheter recordings, before and after sustained CRT treatment. Simulations of biventricular pacing of the heart were performed for 49 pacing sites across the LV free wall, in the model of the patient prior to- and after sustained pacing. The optimal region for LV pacing was determined by the acute haemodynamic response (AHR). After sustained CRT treatment the heart remodels and the models predict that the optimal region for pacing the LV would expand by 46% after this remodeling. The expansion in the optimal LV pacing region after remodeling predicts that if LV lead location was placed within the optimal region prior to CRT treatment, it will remain within the optimal region after sustained pacing.

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