Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence

IMAGEN Consortium

doi:10.1001/jamanetworkopen.2024.25114

Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence

IMAGEN Consortium

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Abstract

IMPORTANCE The development of an alcohol use disorder in adolescence is associated with increased risk of future alcohol dependence. The differential associations of risk factors with alcohol use over the course of 8 years are important for preventive measures. OBJECTIVE To determine the differential associations of risk-taking aspects of personality, social factors, brain functioning, and familial risk with hazardous alcohol use in adolescents over the course of 8 years. DESIGN, SETTING, AND PARTICIPANTS The IMAGEN multicenter longitudinal cohort study included adolescents recruited from European schools in Germany, the UK, France, and Ireland from January 2008 to January 2019. Eligible participants included those with available neuropsychological, self-report, imaging, and genetic data at baseline. Adolescents who were ineligible for magnetic resonance imaging or had serious medical conditions were excluded. Data analysis was conducted from July 2021 to September 2022. EXPOSURE Personality testing, psychosocial factors, brain functioning, and familial risk of alcohol misuse. MAIN OUTCOME AND MEASURES Hazardous alcohol use as measured with the Alcohol Use Disorders Identification Test scores, a main planned outcome of the IMAGEN study. Alcohol misuse trajectories at ages 14, 16, 19, and 22 years were modeled using latent growth curve models. RESULTS A total of 2240 adolescents (1110 female [49.6%] and 1130 male [50.4%]) were included in the study. There was a significant negative association of psychosocial resources (β = -0.29; SE = 0.03; P < .001) with the general risk of alcohol misuse as well as a significant positive association of the risk-taking aspects of personality with the intercept (β = 0.19; SE = 0.04; P < .001). Furthermore, there were significant positive associations of the social domain (β = 0.13; SE = 0.02; P < .001) and the personality domain (β = 0.07; SE = 0.02; P < .001) with trajectories of alcohol misuse development over time (slope). Family history of substance misuse was negatively associated with general risk of alcohol misuse (β = -0.04; SE = 0.02; P = .045) and its development over time (β = -0.03; SE = 0.01; P = .01). Brain functioning showed no significant association with intercept or slope of alcohol misuse in the model. CONCLUSIONS AND RELEVANCE The findings of this cohort study suggest known risk factors of adolescent drinking may contribute differentially to future alcohol misuse. This approach may inform more individualized preventive interventions.

Original language	English
Pages (from-to)	e2425114
Journal	JAMA Network open
Volume	7
Issue number	8
DOIs	https://doi.org/10.1001/jamanetworkopen.2024.25114
Publication status	Published - 16 Aug 2024

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10.1001/jamanetworkopen.2024.25114

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@article{2d71434202144d7fa31499c537cd0250,

title = "Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence",

abstract = "IMPORTANCE The development of an alcohol use disorder in adolescence is associated with increased risk of future alcohol dependence. The differential associations of risk factors with alcohol use over the course of 8 years are important for preventive measures. OBJECTIVE To determine the differential associations of risk-taking aspects of personality, social factors, brain functioning, and familial risk with hazardous alcohol use in adolescents over the course of 8 years. DESIGN, SETTING, AND PARTICIPANTS The IMAGEN multicenter longitudinal cohort study included adolescents recruited from European schools in Germany, the UK, France, and Ireland from January 2008 to January 2019. Eligible participants included those with available neuropsychological, self-report, imaging, and genetic data at baseline. Adolescents who were ineligible for magnetic resonance imaging or had serious medical conditions were excluded. Data analysis was conducted from July 2021 to September 2022. EXPOSURE Personality testing, psychosocial factors, brain functioning, and familial risk of alcohol misuse. MAIN OUTCOME AND MEASURES Hazardous alcohol use as measured with the Alcohol Use Disorders Identification Test scores, a main planned outcome of the IMAGEN study. Alcohol misuse trajectories at ages 14, 16, 19, and 22 years were modeled using latent growth curve models. RESULTS A total of 2240 adolescents (1110 female [49.6%] and 1130 male [50.4%]) were included in the study. There was a significant negative association of psychosocial resources (β = -0.29; SE = 0.03; P < .001) with the general risk of alcohol misuse as well as a significant positive association of the risk-taking aspects of personality with the intercept (β = 0.19; SE = 0.04; P < .001). Furthermore, there were significant positive associations of the social domain (β = 0.13; SE = 0.02; P < .001) and the personality domain (β = 0.07; SE = 0.02; P < .001) with trajectories of alcohol misuse development over time (slope). Family history of substance misuse was negatively associated with general risk of alcohol misuse (β = -0.04; SE = 0.02; P = .045) and its development over time (β = -0.03; SE = 0.01; P = .01). Brain functioning showed no significant association with intercept or slope of alcohol misuse in the model. CONCLUSIONS AND RELEVANCE The findings of this cohort study suggest known risk factors of adolescent drinking may contribute differentially to future alcohol misuse. This approach may inform more individualized preventive interventions.",

author = "{IMAGEN Consortium} and Mira Tschorn and Laura Daedelow and Laura Szalek and Tobias Banaschewski and Bokde, {Arun L.W.} and Sylvane Desrivi{\`e}res and Herta Flor and Antoine Grigis and Hugh Garavan and Penny Gowland and Martinot, {Jean Luc} and Martinot, {Marie Laure Paill{\`e}re} and Eric Artiges and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Luise Poustka and Sarah Hohmann and Christian Buechl and Smolka, {Michael N.} and Nilakshi Vaidya and Henrik Walter and Robert Whelan and Gunter Schumann and Andreas Heinz and Rapp, {Michael A.} and Trevor Robbin and Jeffrey Dalley and Jan Reuter and Anna Cattrell and Tianye Jia and Helen Werts and Lauren Topper and Laurence Reed and Catherine Mallik and Barbara Ruggeri and Gareth Barker and Charlotte Nymberg and Conrod, {Patricia J.} and Lindsay Smith and Eva Loth and Eanna Hanratty and Eleanor Kennedy and Argyris Stringaris and Alex Ing and Gabriel Robert and Christine Macare and Bing Xu and Tao Yu and {Burke Quinlan}, Erin and Craig Newman",

note = "Publisher Copyright: {\textcopyright} 2024 Tschorn M et al.",

year = "2024",

month = aug,

day = "16",

doi = "10.1001/jamanetworkopen.2024.25114",

language = "English",

volume = "7",

pages = "e2425114",

journal = "JAMA Network open",

issn = "2574-3805",

publisher = "American Medical Association",

number = "8",

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TY - JOUR

T1 - Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence

AU - IMAGEN Consortium

AU - Tschorn, Mira

AU - Daedelow, Laura

AU - Szalek, Laura

AU - Banaschewski, Tobias

AU - Bokde, Arun L.W.

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Martinot, Jean Luc

AU - Martinot, Marie Laure Paillère

AU - Artiges, Eric

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Poustka, Luise

AU - Hohmann, Sarah

AU - Buechl, Christian

AU - Smolka, Michael N.

AU - Vaidya, Nilakshi

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Heinz, Andreas

AU - Rapp, Michael A.

AU - Robbin, Trevor

AU - Dalley, Jeffrey

AU - Reuter, Jan

AU - Cattrell, Anna

AU - Jia, Tianye

AU - Werts, Helen

AU - Topper, Lauren

AU - Reed, Laurence

AU - Mallik, Catherine

AU - Ruggeri, Barbara

AU - Barker, Gareth

AU - Nymberg, Charlotte

AU - Conrod, Patricia J.

AU - Smith, Lindsay

AU - Loth, Eva

AU - Hanratty, Eanna

AU - Kennedy, Eleanor

AU - Stringaris, Argyris

AU - Ing, Alex

AU - Robert, Gabriel

AU - Macare, Christine

AU - Xu, Bing

AU - Yu, Tao

AU - Burke Quinlan, Erin

AU - Newman, Craig

PY - 2024/8/16

Y1 - 2024/8/16

N2 - IMPORTANCE The development of an alcohol use disorder in adolescence is associated with increased risk of future alcohol dependence. The differential associations of risk factors with alcohol use over the course of 8 years are important for preventive measures. OBJECTIVE To determine the differential associations of risk-taking aspects of personality, social factors, brain functioning, and familial risk with hazardous alcohol use in adolescents over the course of 8 years. DESIGN, SETTING, AND PARTICIPANTS The IMAGEN multicenter longitudinal cohort study included adolescents recruited from European schools in Germany, the UK, France, and Ireland from January 2008 to January 2019. Eligible participants included those with available neuropsychological, self-report, imaging, and genetic data at baseline. Adolescents who were ineligible for magnetic resonance imaging or had serious medical conditions were excluded. Data analysis was conducted from July 2021 to September 2022. EXPOSURE Personality testing, psychosocial factors, brain functioning, and familial risk of alcohol misuse. MAIN OUTCOME AND MEASURES Hazardous alcohol use as measured with the Alcohol Use Disorders Identification Test scores, a main planned outcome of the IMAGEN study. Alcohol misuse trajectories at ages 14, 16, 19, and 22 years were modeled using latent growth curve models. RESULTS A total of 2240 adolescents (1110 female [49.6%] and 1130 male [50.4%]) were included in the study. There was a significant negative association of psychosocial resources (β = -0.29; SE = 0.03; P < .001) with the general risk of alcohol misuse as well as a significant positive association of the risk-taking aspects of personality with the intercept (β = 0.19; SE = 0.04; P < .001). Furthermore, there were significant positive associations of the social domain (β = 0.13; SE = 0.02; P < .001) and the personality domain (β = 0.07; SE = 0.02; P < .001) with trajectories of alcohol misuse development over time (slope). Family history of substance misuse was negatively associated with general risk of alcohol misuse (β = -0.04; SE = 0.02; P = .045) and its development over time (β = -0.03; SE = 0.01; P = .01). Brain functioning showed no significant association with intercept or slope of alcohol misuse in the model. CONCLUSIONS AND RELEVANCE The findings of this cohort study suggest known risk factors of adolescent drinking may contribute differentially to future alcohol misuse. This approach may inform more individualized preventive interventions.

AB - IMPORTANCE The development of an alcohol use disorder in adolescence is associated with increased risk of future alcohol dependence. The differential associations of risk factors with alcohol use over the course of 8 years are important for preventive measures. OBJECTIVE To determine the differential associations of risk-taking aspects of personality, social factors, brain functioning, and familial risk with hazardous alcohol use in adolescents over the course of 8 years. DESIGN, SETTING, AND PARTICIPANTS The IMAGEN multicenter longitudinal cohort study included adolescents recruited from European schools in Germany, the UK, France, and Ireland from January 2008 to January 2019. Eligible participants included those with available neuropsychological, self-report, imaging, and genetic data at baseline. Adolescents who were ineligible for magnetic resonance imaging or had serious medical conditions were excluded. Data analysis was conducted from July 2021 to September 2022. EXPOSURE Personality testing, psychosocial factors, brain functioning, and familial risk of alcohol misuse. MAIN OUTCOME AND MEASURES Hazardous alcohol use as measured with the Alcohol Use Disorders Identification Test scores, a main planned outcome of the IMAGEN study. Alcohol misuse trajectories at ages 14, 16, 19, and 22 years were modeled using latent growth curve models. RESULTS A total of 2240 adolescents (1110 female [49.6%] and 1130 male [50.4%]) were included in the study. There was a significant negative association of psychosocial resources (β = -0.29; SE = 0.03; P < .001) with the general risk of alcohol misuse as well as a significant positive association of the risk-taking aspects of personality with the intercept (β = 0.19; SE = 0.04; P < .001). Furthermore, there were significant positive associations of the social domain (β = 0.13; SE = 0.02; P < .001) and the personality domain (β = 0.07; SE = 0.02; P < .001) with trajectories of alcohol misuse development over time (slope). Family history of substance misuse was negatively associated with general risk of alcohol misuse (β = -0.04; SE = 0.02; P = .045) and its development over time (β = -0.03; SE = 0.01; P = .01). Brain functioning showed no significant association with intercept or slope of alcohol misuse in the model. CONCLUSIONS AND RELEVANCE The findings of this cohort study suggest known risk factors of adolescent drinking may contribute differentially to future alcohol misuse. This approach may inform more individualized preventive interventions.

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U2 - 10.1001/jamanetworkopen.2024.25114

DO - 10.1001/jamanetworkopen.2024.25114

M3 - Article

C2 - 39150713

AN - SCOPUS:85201473209

SN - 2574-3805

VL - 7

SP - e2425114

JO - JAMA Network open

JF - JAMA Network open

IS - 8

ER -

Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence

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