Personalized modeling pipeline for left atrial electromechanics

Thomas Fastl*, Catalina Tobon Gomez, William A. Crozier, John Whitaker, Ronak Rajani, Karen P. McCarthy, Damian Sanchez-Quintana, Siew Y. Ho, Mark O'Neill, Gernot Plank, Martin J. Bishop, Steven Niederer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingOther chapter contributionpeer-review

4 Citations (Scopus)


Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by uncoordinated atrial activation with consequent deterioration of mechanical function. Personalized computational modeling provides a novel framework for integrating and interpreting the combined role of atrial electrophysiology and mechanics in AF development and sustenance. Coronary computed tomography angiography data were segmented using a threshold-based approach and the smoothed voxel representation was dis-cretized into a high-resolution tetrahedral finite element (FE) mesh. To estimate the complex left atrial fiber architecture, individual fiber fields were generated according to morphological data on the endo- and epicardial surfaces based on local solutions of Laplace's equation and trans-murally interpolated to all tetrahedral elements. Personalized geometrical models included the heterogeneous thickness distribution of the left atrial myocardium and subsequent discretization led to high-fidelity tetrahedral FE meshes. The novel algorithm for (automated) incorporation of the left atrial fiber architecture provided a realistic estimate of the atrial microstructure and was able to qualitatively capture all important fiber bundles. The established modeling pipeline provides a robust framework for the rapid development of personalized model cohorts and facilitates simulations of atrial electromechanics.

Original languageEnglish
Title of host publicationComputing in Cardiology Conference, CinC 2016
PublisherIEEE Computer Society
Number of pages4
ISBN (Electronic)9781509008964
Publication statusPublished - 1 Mar 2017
Event43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada
Duration: 11 Sept 201614 Sept 2016


Conference43rd Computing in Cardiology Conference, CinC 2016


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