Pharmacological magnetic resonance imaging of transmitter mechanisms for large-scale brain adaptivity

E  Bullmore; F  Zelaya; C  Long; Steven Williams; J  Suckling; G  Honey; L  Reed; P  Fletcher; J  Brown; V  Ng; C  Routledge

Pharmacological magnetic resonance imaging of transmitter mechanisms for large-scale brain adaptivity

E Bullmore, F Zelaya, C Long, Steven Williams, J Suckling, G Honey, L Reed, P Fletcher, J Brown, V Ng, C Routledge

Inst Psychiat, Dept Psychiat

Research output: Chapter in Book/Report/Conference proceeding › Conference paper

Abstract

Brain activation is adaptive to task difficulty and practice. We used functional MRI to map brain systems activated by an object location learning task in 24 healthy elderly volunteers each scanned following placebo and two of four active drugs studied. We distinguished a fronto-striatal system adaptive to difficulty from a posterior system adaptive to practice. Fronto-striatal response to increased cognitive load was significantly attenuated by scopolamine, sulpiride and methylphenidate; practice effects were not modulated by these drugs. Difficulty and practice evoke anatomically and pharmacologically dissociable brain activation dynamics, which are probably mediated by different neurotransmitter systems in humans.

Original language	English
Title of host publication	PSYCHIATRIC NEUROIMAGING
Editors	V Ng, GJ Barker, T Hendler
Place of Publication	AMSTERDAM
Publisher	I O S PRESS
Pages	170-176
Number of pages	7
ISBN (Print)	1-58603-344-1
Publication status	Published - 2003
Event	NATO Advanced Research Workshop on Psychiatric Neuroimaging - Chiavari Duration: 29 Sept 2002 → 1 Oct 2002

Conference

Conference	NATO Advanced Research Workshop on Psychiatric Neuroimaging
City	Chiavari
Period	29/09/2002 → 1/10/2002

Cite this

@inbook{1ce778ce5070453bb357212ae74e63e2,

title = "Pharmacological magnetic resonance imaging of transmitter mechanisms for large-scale brain adaptivity",

abstract = "Brain activation is adaptive to task difficulty and practice. We used functional MRI to map brain systems activated by an object location learning task in 24 healthy elderly volunteers each scanned following placebo and two of four active drugs studied. We distinguished a fronto-striatal system adaptive to difficulty from a posterior system adaptive to practice. Fronto-striatal response to increased cognitive load was significantly attenuated by scopolamine, sulpiride and methylphenidate; practice effects were not modulated by these drugs. Difficulty and practice evoke anatomically and pharmacologically dissociable brain activation dynamics, which are probably mediated by different neurotransmitter systems in humans.",

author = "E Bullmore and F Zelaya and C Long and Steven Williams and J Suckling and G Honey and L Reed and P Fletcher and J Brown and V Ng and C Routledge",

year = "2003",

language = "English",

isbn = "1-58603-344-1",

pages = "170--176",

editor = "V Ng and GJ Barker and T Hendler",

booktitle = "PSYCHIATRIC NEUROIMAGING",

publisher = "I O S PRESS",

note = "NATO Advanced Research Workshop on Psychiatric Neuroimaging ; Conference date: 29-09-2002 Through 01-10-2002",

}

Bullmore, E, Zelaya, F, Long, C, Williams, S , Suckling, J, Honey, G, Reed, L, Fletcher, P, Brown, J, Ng, V & Routledge, C 2003, Pharmacological magnetic resonance imaging of transmitter mechanisms for large-scale brain adaptivity. in V Ng, GJ Barker & T Hendler (eds), PSYCHIATRIC NEUROIMAGING. I O S PRESS, AMSTERDAM, pp. 170-176, NATO Advanced Research Workshop on Psychiatric Neuroimaging, Chiavari, 29/09/2002.

TY - CHAP

T1 - Pharmacological magnetic resonance imaging of transmitter mechanisms for large-scale brain adaptivity

AU - Bullmore, E

AU - Zelaya, F

AU - Long, C

AU - Williams, Steven

AU - Suckling, J

AU - Honey, G

AU - Reed, L

AU - Fletcher, P

AU - Brown, J

AU - Ng, V

AU - Routledge, C

PY - 2003

Y1 - 2003

N2 - Brain activation is adaptive to task difficulty and practice. We used functional MRI to map brain systems activated by an object location learning task in 24 healthy elderly volunteers each scanned following placebo and two of four active drugs studied. We distinguished a fronto-striatal system adaptive to difficulty from a posterior system adaptive to practice. Fronto-striatal response to increased cognitive load was significantly attenuated by scopolamine, sulpiride and methylphenidate; practice effects were not modulated by these drugs. Difficulty and practice evoke anatomically and pharmacologically dissociable brain activation dynamics, which are probably mediated by different neurotransmitter systems in humans.

AB - Brain activation is adaptive to task difficulty and practice. We used functional MRI to map brain systems activated by an object location learning task in 24 healthy elderly volunteers each scanned following placebo and two of four active drugs studied. We distinguished a fronto-striatal system adaptive to difficulty from a posterior system adaptive to practice. Fronto-striatal response to increased cognitive load was significantly attenuated by scopolamine, sulpiride and methylphenidate; practice effects were not modulated by these drugs. Difficulty and practice evoke anatomically and pharmacologically dissociable brain activation dynamics, which are probably mediated by different neurotransmitter systems in humans.

M3 - Conference paper

SN - 1-58603-344-1

SP - 170

EP - 176

BT - PSYCHIATRIC NEUROIMAGING

A2 - Ng, V

A2 - Barker, GJ

A2 - Hendler, T

PB - I O S PRESS

CY - AMSTERDAM

T2 - NATO Advanced Research Workshop on Psychiatric Neuroimaging

Y2 - 29 September 2002 through 1 October 2002

ER -

Pharmacological magnetic resonance imaging of transmitter mechanisms for large-scale brain adaptivity

Abstract

Conference

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