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Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice

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Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice. / Egeland, Martin; Zhang, Xiaoqun; Millan, Mark J.; Mocaer, Elisabeth; Svenningsson, Per.

In: Journal of Neurochemistry, Vol. 123, No. 5, 01.12.2012, p. 811-823.

Research output: Contribution to journalArticle

Harvard

Egeland, M, Zhang, X, Millan, MJ, Mocaer, E & Svenningsson, P 2012, 'Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice', Journal of Neurochemistry, vol. 123, no. 5, pp. 811-823. https://doi.org/10.1111/jnc.12011

APA

Egeland, M., Zhang, X., Millan, M. J., Mocaer, E., & Svenningsson, P. (2012). Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice. Journal of Neurochemistry, 123(5), 811-823. https://doi.org/10.1111/jnc.12011

Vancouver

Egeland M, Zhang X, Millan MJ, Mocaer E, Svenningsson P. Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice. Journal of Neurochemistry. 2012 Dec 1;123(5):811-823. https://doi.org/10.1111/jnc.12011

Author

Egeland, Martin ; Zhang, Xiaoqun ; Millan, Mark J. ; Mocaer, Elisabeth ; Svenningsson, Per. / Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice. In: Journal of Neurochemistry. 2012 ; Vol. 123, No. 5. pp. 811-823.

Bibtex Download

@article{68f770e69d4c43e8a8bb0c818975cdce,
title = "Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice",
abstract = "Dopamine plays an important role in cellular processes controlling the functional and structural plasticity of neurons, as well as their generation and proliferation, both in the developing and the adult brain. The precise roles of individual dopamine receptors subtypes in adult neurogenesis remain poorly defined, although D3 receptors are known to be involved in neurogenesis in the subventricular zone. By contrast, very few studies have addressed the influence of dopamine and D3 receptors upon neurogenesis in the subgranular zone of the hippocampus, an issue addressed herein employing constitutive D3 receptor knockout mice, or chronic exposure to the preferential D3 receptor antagonist, S33138. D3 receptor knockout mice revealed increased baseline levels of cell proliferation and ongoing neurogenesis, as measured both using Ki-67 and doublecortin, whereas there was no difference in cell survival as measured by BrdU (5-bromo-2'-deoxyuridine). Chronic administration of S33138 was shown to be functionally active in enhancing levels of the plasticity-related molecule, delta-FosB, in the D3 receptor-rich nucleus accumbens. In accordance with the stimulated neurogenesis seen in D3 receptor knockout mice, S33138 increased proliferation in wild-type mice. These observations suggest that D3 receptors exert a tonic, constitutive inhibitory influence upon adult hippocampal neurogenesis.",
keywords = "BrdU, DCX, delta-FosB, doublecortin, Ki-67, neurogenesis, POTENTIAL ANTIPSYCHOTIC AGENT, ELEMENT-BINDING PROTEIN, SUBVENTRICULAR ZONE, COGNITIVE IMPAIRMENT, NEUROTROPHIC FACTOR, PARKINSONS-DISEASE, DEFICIENT MICE, D-3 RECEPTORS, DELTA-FOSB, NEUROGENESIS",
author = "Martin Egeland and Xiaoqun Zhang and Millan, {Mark J.} and Elisabeth Mocaer and Per Svenningsson",
year = "2012",
month = dec,
day = "1",
doi = "10.1111/jnc.12011",
language = "English",
volume = "123",
pages = "811--823",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice

AU - Egeland, Martin

AU - Zhang, Xiaoqun

AU - Millan, Mark J.

AU - Mocaer, Elisabeth

AU - Svenningsson, Per

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Dopamine plays an important role in cellular processes controlling the functional and structural plasticity of neurons, as well as their generation and proliferation, both in the developing and the adult brain. The precise roles of individual dopamine receptors subtypes in adult neurogenesis remain poorly defined, although D3 receptors are known to be involved in neurogenesis in the subventricular zone. By contrast, very few studies have addressed the influence of dopamine and D3 receptors upon neurogenesis in the subgranular zone of the hippocampus, an issue addressed herein employing constitutive D3 receptor knockout mice, or chronic exposure to the preferential D3 receptor antagonist, S33138. D3 receptor knockout mice revealed increased baseline levels of cell proliferation and ongoing neurogenesis, as measured both using Ki-67 and doublecortin, whereas there was no difference in cell survival as measured by BrdU (5-bromo-2'-deoxyuridine). Chronic administration of S33138 was shown to be functionally active in enhancing levels of the plasticity-related molecule, delta-FosB, in the D3 receptor-rich nucleus accumbens. In accordance with the stimulated neurogenesis seen in D3 receptor knockout mice, S33138 increased proliferation in wild-type mice. These observations suggest that D3 receptors exert a tonic, constitutive inhibitory influence upon adult hippocampal neurogenesis.

AB - Dopamine plays an important role in cellular processes controlling the functional and structural plasticity of neurons, as well as their generation and proliferation, both in the developing and the adult brain. The precise roles of individual dopamine receptors subtypes in adult neurogenesis remain poorly defined, although D3 receptors are known to be involved in neurogenesis in the subventricular zone. By contrast, very few studies have addressed the influence of dopamine and D3 receptors upon neurogenesis in the subgranular zone of the hippocampus, an issue addressed herein employing constitutive D3 receptor knockout mice, or chronic exposure to the preferential D3 receptor antagonist, S33138. D3 receptor knockout mice revealed increased baseline levels of cell proliferation and ongoing neurogenesis, as measured both using Ki-67 and doublecortin, whereas there was no difference in cell survival as measured by BrdU (5-bromo-2'-deoxyuridine). Chronic administration of S33138 was shown to be functionally active in enhancing levels of the plasticity-related molecule, delta-FosB, in the D3 receptor-rich nucleus accumbens. In accordance with the stimulated neurogenesis seen in D3 receptor knockout mice, S33138 increased proliferation in wild-type mice. These observations suggest that D3 receptors exert a tonic, constitutive inhibitory influence upon adult hippocampal neurogenesis.

KW - BrdU

KW - DCX

KW - delta-FosB

KW - doublecortin

KW - Ki-67

KW - neurogenesis

KW - POTENTIAL ANTIPSYCHOTIC AGENT

KW - ELEMENT-BINDING PROTEIN

KW - SUBVENTRICULAR ZONE

KW - COGNITIVE IMPAIRMENT

KW - NEUROTROPHIC FACTOR

KW - PARKINSONS-DISEASE

KW - DEFICIENT MICE

KW - D-3 RECEPTORS

KW - DELTA-FOSB

KW - NEUROGENESIS

U2 - 10.1111/jnc.12011

DO - 10.1111/jnc.12011

M3 - Article

VL - 123

SP - 811

EP - 823

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

IS - 5

ER -

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