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Pharmacological strategies for targeting platelet activation in asthma

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Pharmacological strategies for targeting platelet activation in asthma. / Pitchford, Simon; Cleary, Simon; Arkless, Kate; Amison, Richard.

In: Current Opinion in Pharmacology, Vol. 46, 01.06.2019, p. 55-64.

Research output: Contribution to journalReview article

Harvard

Pitchford, S, Cleary, S, Arkless, K & Amison, R 2019, 'Pharmacological strategies for targeting platelet activation in asthma', Current Opinion in Pharmacology, vol. 46, pp. 55-64. https://doi.org/10.1016/j.coph.2019.03.012

APA

Pitchford, S., Cleary, S., Arkless, K., & Amison, R. (2019). Pharmacological strategies for targeting platelet activation in asthma. Current Opinion in Pharmacology, 46, 55-64. https://doi.org/10.1016/j.coph.2019.03.012

Vancouver

Pitchford S, Cleary S, Arkless K, Amison R. Pharmacological strategies for targeting platelet activation in asthma. Current Opinion in Pharmacology. 2019 Jun 1;46:55-64. https://doi.org/10.1016/j.coph.2019.03.012

Author

Pitchford, Simon ; Cleary, Simon ; Arkless, Kate ; Amison, Richard. / Pharmacological strategies for targeting platelet activation in asthma. In: Current Opinion in Pharmacology. 2019 ; Vol. 46. pp. 55-64.

Bibtex Download

@article{a165530ea4144f08801c0b845f45ce34,
title = "Pharmacological strategies for targeting platelet activation in asthma",
abstract = "The activation of platelets during host defence and inflammatory disorders has become increasingly documented. Clinical studies of patients with asthma reveal heightened platelet activation and accumulation into lung tissue. Accompanying studies in animal models of allergic lung inflammation, using protocols of experimentally induced thrombocytopenia proclaim an important role for platelets during the leukocyte recruitment cascade, tissue integrity, and lung function. The functions of platelets during these inflammatory events are clearly distinct to platelet functions during haemostasis and clot formation, and have led to the concept that a dichotomy (or polytomy, depending on what else platelets do) in platelet activation exists. The platelet, therefore, presents us with novel opportunities for modulating these inflammatory responses. This review discusses the rationale and effectiveness of current anti-platelet drugs in their use to supress inflammation with regard to asthma, and the need to consider novel possibilities for pharmacological modulation of platelet function associated with inflammation that are pharmacologically distinct to current anti-platelet therapies.",
author = "Simon Pitchford and Simon Cleary and Kate Arkless and Richard Amison",
year = "2019",
month = jun,
day = "1",
doi = "10.1016/j.coph.2019.03.012",
language = "English",
volume = "46",
pages = "55--64",
journal = "Current Opinion in Pharmacology",
issn = "1471-4892",
publisher = "Elsevier BV",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Pharmacological strategies for targeting platelet activation in asthma

AU - Pitchford, Simon

AU - Cleary, Simon

AU - Arkless, Kate

AU - Amison, Richard

PY - 2019/6/1

Y1 - 2019/6/1

N2 - The activation of platelets during host defence and inflammatory disorders has become increasingly documented. Clinical studies of patients with asthma reveal heightened platelet activation and accumulation into lung tissue. Accompanying studies in animal models of allergic lung inflammation, using protocols of experimentally induced thrombocytopenia proclaim an important role for platelets during the leukocyte recruitment cascade, tissue integrity, and lung function. The functions of platelets during these inflammatory events are clearly distinct to platelet functions during haemostasis and clot formation, and have led to the concept that a dichotomy (or polytomy, depending on what else platelets do) in platelet activation exists. The platelet, therefore, presents us with novel opportunities for modulating these inflammatory responses. This review discusses the rationale and effectiveness of current anti-platelet drugs in their use to supress inflammation with regard to asthma, and the need to consider novel possibilities for pharmacological modulation of platelet function associated with inflammation that are pharmacologically distinct to current anti-platelet therapies.

AB - The activation of platelets during host defence and inflammatory disorders has become increasingly documented. Clinical studies of patients with asthma reveal heightened platelet activation and accumulation into lung tissue. Accompanying studies in animal models of allergic lung inflammation, using protocols of experimentally induced thrombocytopenia proclaim an important role for platelets during the leukocyte recruitment cascade, tissue integrity, and lung function. The functions of platelets during these inflammatory events are clearly distinct to platelet functions during haemostasis and clot formation, and have led to the concept that a dichotomy (or polytomy, depending on what else platelets do) in platelet activation exists. The platelet, therefore, presents us with novel opportunities for modulating these inflammatory responses. This review discusses the rationale and effectiveness of current anti-platelet drugs in their use to supress inflammation with regard to asthma, and the need to consider novel possibilities for pharmacological modulation of platelet function associated with inflammation that are pharmacologically distinct to current anti-platelet therapies.

UR - http://www.scopus.com/inward/record.url?scp=85064430058&partnerID=8YFLogxK

U2 - 10.1016/j.coph.2019.03.012

DO - 10.1016/j.coph.2019.03.012

M3 - Review article

AN - SCOPUS:85064430058

VL - 46

SP - 55

EP - 64

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

SN - 1471-4892

ER -

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