TY - JOUR
T1 - Phase II mixed methods' feasibility cluster randomised controlled trial of a novel community-based enhanced care intervention to improve person-centred outcomes for people living with HIV in Ghana
AU - Abboah-Offei, Mary
AU - Bristowe, Katherine
AU - Vanderpuye-Donton, Naa Ashiley
AU - Ansa, Gloria
AU - Oppong-Agyei, Yaa Dabboah
AU - Abas, Melanie
AU - Higginson, Irene
AU - Harding, Richard
PY - 2020/5/13
Y1 - 2020/5/13
N2 - Person-centred care (PCC) for people living with HIV (PLWH) is a global goal for WHO and the UNAIDS strategy. We aimed to develop a novel person-centred intervention for community providers, test the feasibility of participant recruitment and retention, intervention delivery and to establish acceptability. Findings from qualitative interviews with PLWH and healthcare professionals were mapped onto a PCC theory in an expert intervention development workshop. A parallel feasibility cluster randomised controlled trial (cRCT) was conducted. We randomly assigned clusters (1:1) either to intervention or to standard care. The primary outcome was trial recruitment and retention. We screened 83 PLWH, enrolled 60 with 30 allocated to each arm. Recruitment and retention rates were 87% and 97%, respectively. Potential effect size achieved at final timepoint: a measure of person-centred outcomes [0.7 (95% CI 0.17-1.23) p < 0.001]; MOSHIV [0.7 (95% CI 0.17-1.23) p < 0.001]; Patient Experience Questionnaire [0.8 (95% CI 0.27-1.31) p < 0.001]; CARE Measure [1.0 (95% CI 0.45-1.55) p < 0.001], POSITIVE OUTCOMES [0.7 (95% CI 0.17-1.23) p < 0.001]. Post-trial interviews revealed general acceptability of the intervention. The results confirm the feasibility and justify a definitive cRCT of the enhanced care intervention to improve person-centred outcomes for PLWH.Trial registration number ISRCTN13630241.
AB - Person-centred care (PCC) for people living with HIV (PLWH) is a global goal for WHO and the UNAIDS strategy. We aimed to develop a novel person-centred intervention for community providers, test the feasibility of participant recruitment and retention, intervention delivery and to establish acceptability. Findings from qualitative interviews with PLWH and healthcare professionals were mapped onto a PCC theory in an expert intervention development workshop. A parallel feasibility cluster randomised controlled trial (cRCT) was conducted. We randomly assigned clusters (1:1) either to intervention or to standard care. The primary outcome was trial recruitment and retention. We screened 83 PLWH, enrolled 60 with 30 allocated to each arm. Recruitment and retention rates were 87% and 97%, respectively. Potential effect size achieved at final timepoint: a measure of person-centred outcomes [0.7 (95% CI 0.17-1.23) p < 0.001]; MOSHIV [0.7 (95% CI 0.17-1.23) p < 0.001]; Patient Experience Questionnaire [0.8 (95% CI 0.27-1.31) p < 0.001]; CARE Measure [1.0 (95% CI 0.45-1.55) p < 0.001], POSITIVE OUTCOMES [0.7 (95% CI 0.17-1.23) p < 0.001]. Post-trial interviews revealed general acceptability of the intervention. The results confirm the feasibility and justify a definitive cRCT of the enhanced care intervention to improve person-centred outcomes for PLWH.Trial registration number ISRCTN13630241.
KW - HIV/AIDS
KW - Person-centred care
KW - community-based care
KW - ghana
KW - holistic assessment
UR - http://www.scopus.com/inward/record.url?scp=85081741288&partnerID=8YFLogxK
U2 - 10.1080/09540121.2020.1739217
DO - 10.1080/09540121.2020.1739217
M3 - Article
C2 - 32164440
SN - 0954-0121
VL - 32
SP - 107
EP - 118
JO - Aids Care
JF - Aids Care
IS - sup2
ER -