Phenobarbital blocks the lung edema induced by centrally injected tityustoxin in adult Wistar rats

Michel Bernanos, T Moraes-Santos, M F D Moraes

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    33 Citations (Scopus)

    Abstract

    The aim of this study was to evaluate the ability of phenobarbital to block the lung edema observed after intracerebroventricular (icv) injections of tityustoxin (TsTX); a toxic fraction of the Tityus serrulatus venom. We injected 1.74 mug icv (1.0 mul) of TsTX in Wistar rats pre-treated with 0.1 ml intramuscular injections of sterile saline or phenobarbital (60 or 170 mg/kg body weight). After the experiments the lungs were harvested and the pulmonary index (PI = lung/body weight x 100) calculated. The animals pre-treated with saline developed severe lung edema (PI = 1.8 +/- 0.2) after TsTX icv injection whereas those that received 170 mg/kg of phenobarbital presented no lung edema (PI = 0.71 +/- 0.02). Our results suggest that the lung edema induced by TsTX is of neurogenic nature and that 170 mg/kg of phenobarbital blocks TsTX induced lung edema. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)119-122
    Number of pages4
    JournalNeuroscience Letters
    Volume332
    Issue number2
    Publication statusPublished - 31 Oct 2002

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