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Phosphatidylcholine containing long chain omega-3 fatty acids: A treatment adjunct for patients with anorexia nervosa?

Research output: Contribution to journalReview article

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Phosphatidylcholine containing long chain omega-3 fatty acids : A treatment adjunct for patients with anorexia nervosa? / Patsalos, Olivia; Mavrogiannidis, Theodoros; Dalton, Bethan; Field, Catherine J.; Himmerich, Hubertus.

In: Psychiatria Danubina, Vol. 32, No. 1, 01.01.2020, p. 55-59.

Research output: Contribution to journalReview article

Harvard

Patsalos, O, Mavrogiannidis, T, Dalton, B, Field, CJ & Himmerich, H 2020, 'Phosphatidylcholine containing long chain omega-3 fatty acids: A treatment adjunct for patients with anorexia nervosa?', Psychiatria Danubina, vol. 32, no. 1, pp. 55-59. https://doi.org/10.24869/psyd.2020.55

APA

Patsalos, O., Mavrogiannidis, T., Dalton, B., Field, C. J., & Himmerich, H. (2020). Phosphatidylcholine containing long chain omega-3 fatty acids: A treatment adjunct for patients with anorexia nervosa? Psychiatria Danubina, 32(1), 55-59. https://doi.org/10.24869/psyd.2020.55

Vancouver

Patsalos O, Mavrogiannidis T, Dalton B, Field CJ, Himmerich H. Phosphatidylcholine containing long chain omega-3 fatty acids: A treatment adjunct for patients with anorexia nervosa? Psychiatria Danubina. 2020 Jan 1;32(1):55-59. https://doi.org/10.24869/psyd.2020.55

Author

Patsalos, Olivia ; Mavrogiannidis, Theodoros ; Dalton, Bethan ; Field, Catherine J. ; Himmerich, Hubertus. / Phosphatidylcholine containing long chain omega-3 fatty acids : A treatment adjunct for patients with anorexia nervosa?. In: Psychiatria Danubina. 2020 ; Vol. 32, No. 1. pp. 55-59.

Bibtex Download

@article{bac2741a813f4f90a1c04cdc6597f507,
title = "Phosphatidylcholine containing long chain omega-3 fatty acids: A treatment adjunct for patients with anorexia nervosa?",
abstract = "Background: Anorexia nervosa (AN) is a serious mental disorder with a high mortality rate and often a chronic course. In contrast to many other common mental disorders, there is no drug therapy approved for AN. Methods: We performed a narrative literature review to consider whether a choline-containing molecule, such as phosphatidylcholine (PC), with an omega (Ȧ)-3 long chain polyunsaturated fatty acid (LCPUFA) could be a potential future medicinal treatment for AN. Results: Choline and LCPUFAs have individually shown benefit for mental health. Case series and pilot studies suggest Ȧ-3 LCPUFAs may be effective in eating disorders. However, pharmacodynamic and pharmacokinetic considerations suggest a greater benefit from the combination of both components. Conclusion: The combination of a choline-containing molecule with an Ȧ-3 LCPUFA may be clinically effective and well tolerated. This idea is supported by the current literature on the role of inflammation, the microbiome, the gut-brain-axis, hormonal, neurotransmitter and intracellular signalling, and on the structure and fluidity of nerve cells membranes in patients with AN.",
keywords = "Anorexia nervosa, Choline, Cytokines, Omega-3 fatty acids, Phosphatidylcholine",
author = "Olivia Patsalos and Theodoros Mavrogiannidis and Bethan Dalton and Field, {Catherine J.} and Hubertus Himmerich",
year = "2020",
month = "1",
day = "1",
doi = "10.24869/psyd.2020.55",
language = "English",
volume = "32",
pages = "55--59",
journal = "Psychiatria Danubina",
issn = "0353-5053",
publisher = "Medicinska Naklada Zagreb",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Phosphatidylcholine containing long chain omega-3 fatty acids

T2 - A treatment adjunct for patients with anorexia nervosa?

AU - Patsalos, Olivia

AU - Mavrogiannidis, Theodoros

AU - Dalton, Bethan

AU - Field, Catherine J.

AU - Himmerich, Hubertus

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Background: Anorexia nervosa (AN) is a serious mental disorder with a high mortality rate and often a chronic course. In contrast to many other common mental disorders, there is no drug therapy approved for AN. Methods: We performed a narrative literature review to consider whether a choline-containing molecule, such as phosphatidylcholine (PC), with an omega (Ȧ)-3 long chain polyunsaturated fatty acid (LCPUFA) could be a potential future medicinal treatment for AN. Results: Choline and LCPUFAs have individually shown benefit for mental health. Case series and pilot studies suggest Ȧ-3 LCPUFAs may be effective in eating disorders. However, pharmacodynamic and pharmacokinetic considerations suggest a greater benefit from the combination of both components. Conclusion: The combination of a choline-containing molecule with an Ȧ-3 LCPUFA may be clinically effective and well tolerated. This idea is supported by the current literature on the role of inflammation, the microbiome, the gut-brain-axis, hormonal, neurotransmitter and intracellular signalling, and on the structure and fluidity of nerve cells membranes in patients with AN.

AB - Background: Anorexia nervosa (AN) is a serious mental disorder with a high mortality rate and often a chronic course. In contrast to many other common mental disorders, there is no drug therapy approved for AN. Methods: We performed a narrative literature review to consider whether a choline-containing molecule, such as phosphatidylcholine (PC), with an omega (Ȧ)-3 long chain polyunsaturated fatty acid (LCPUFA) could be a potential future medicinal treatment for AN. Results: Choline and LCPUFAs have individually shown benefit for mental health. Case series and pilot studies suggest Ȧ-3 LCPUFAs may be effective in eating disorders. However, pharmacodynamic and pharmacokinetic considerations suggest a greater benefit from the combination of both components. Conclusion: The combination of a choline-containing molecule with an Ȧ-3 LCPUFA may be clinically effective and well tolerated. This idea is supported by the current literature on the role of inflammation, the microbiome, the gut-brain-axis, hormonal, neurotransmitter and intracellular signalling, and on the structure and fluidity of nerve cells membranes in patients with AN.

KW - Anorexia nervosa

KW - Choline

KW - Cytokines

KW - Omega-3 fatty acids

KW - Phosphatidylcholine

UR - http://www.scopus.com/inward/record.url?scp=85083755688&partnerID=8YFLogxK

U2 - 10.24869/psyd.2020.55

DO - 10.24869/psyd.2020.55

M3 - Review article

C2 - 32303030

AN - SCOPUS:85083755688

VL - 32

SP - 55

EP - 59

JO - Psychiatria Danubina

JF - Psychiatria Danubina

SN - 0353-5053

IS - 1

ER -

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