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Phosphorylation of Drebrin and Its Role in Neuritogenesis

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Phosphorylation of Drebrin and Its Role in Neuritogenesis. / Gordon-Weeks, Phillip R.

In: Advances in Experimental Medicine And Biology, Vol. 1006, 2017, p. 49-60.

Research output: Contribution to journalArticle

Harvard

Gordon-Weeks, PR 2017, 'Phosphorylation of Drebrin and Its Role in Neuritogenesis', Advances in Experimental Medicine And Biology, vol. 1006, pp. 49-60. https://doi.org/10.1007/978-4-431-56550-5_4

APA

Gordon-Weeks, P. R. (2017). Phosphorylation of Drebrin and Its Role in Neuritogenesis. Advances in Experimental Medicine And Biology, 1006, 49-60. https://doi.org/10.1007/978-4-431-56550-5_4

Vancouver

Gordon-Weeks PR. Phosphorylation of Drebrin and Its Role in Neuritogenesis. Advances in Experimental Medicine And Biology. 2017;1006:49-60. https://doi.org/10.1007/978-4-431-56550-5_4

Author

Gordon-Weeks, Phillip R. / Phosphorylation of Drebrin and Its Role in Neuritogenesis. In: Advances in Experimental Medicine And Biology. 2017 ; Vol. 1006. pp. 49-60.

Bibtex Download

@article{730c1fbfa540490cba6c8213ad8a9c9d,
title = "Phosphorylation of Drebrin and Its Role in Neuritogenesis",
abstract = "Neuritogenesis is an early event in neuronal development in which newborn neurons first form growth cones, as a prerequisite for the formation of axons and dendrites. Growth cones emerge from segmented regions of the lamellipodium of embryonic neurons and grow away from the cell body leaving behind a neurite that will eventually polarise into an axon or dendrite. Growth cones also function to navigate precise routes through the embryo to locate an appropriate synaptic partner. Dynamic interactions between two components of the neuronal cytoskeleton, actin filaments and microtubules, are known to be essential for growth cone formation and hence neuritogenesis. The molecular mechanisms that coordinate interactions between actin filaments and dynamic microtubules during neuritogenesis are beginning to be understood. One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 phosphorylation of drebrin but the upstream elements in the pathway have yet to be identified.",
keywords = "Journal Article",
author = "Gordon-Weeks, {Phillip R}",
year = "2017",
doi = "10.1007/978-4-431-56550-5_4",
language = "English",
volume = "1006",
pages = "49--60",
journal = "Advances in Experimental Medicine And Biology",
issn = "0065-2598",
publisher = "Springer New York",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Phosphorylation of Drebrin and Its Role in Neuritogenesis

AU - Gordon-Weeks, Phillip R

PY - 2017

Y1 - 2017

N2 - Neuritogenesis is an early event in neuronal development in which newborn neurons first form growth cones, as a prerequisite for the formation of axons and dendrites. Growth cones emerge from segmented regions of the lamellipodium of embryonic neurons and grow away from the cell body leaving behind a neurite that will eventually polarise into an axon or dendrite. Growth cones also function to navigate precise routes through the embryo to locate an appropriate synaptic partner. Dynamic interactions between two components of the neuronal cytoskeleton, actin filaments and microtubules, are known to be essential for growth cone formation and hence neuritogenesis. The molecular mechanisms that coordinate interactions between actin filaments and dynamic microtubules during neuritogenesis are beginning to be understood. One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 phosphorylation of drebrin but the upstream elements in the pathway have yet to be identified.

AB - Neuritogenesis is an early event in neuronal development in which newborn neurons first form growth cones, as a prerequisite for the formation of axons and dendrites. Growth cones emerge from segmented regions of the lamellipodium of embryonic neurons and grow away from the cell body leaving behind a neurite that will eventually polarise into an axon or dendrite. Growth cones also function to navigate precise routes through the embryo to locate an appropriate synaptic partner. Dynamic interactions between two components of the neuronal cytoskeleton, actin filaments and microtubules, are known to be essential for growth cone formation and hence neuritogenesis. The molecular mechanisms that coordinate interactions between actin filaments and dynamic microtubules during neuritogenesis are beginning to be understood. One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 phosphorylation of drebrin but the upstream elements in the pathway have yet to be identified.

KW - Journal Article

U2 - 10.1007/978-4-431-56550-5_4

DO - 10.1007/978-4-431-56550-5_4

M3 - Article

C2 - 28865014

VL - 1006

SP - 49

EP - 60

JO - Advances in Experimental Medicine And Biology

JF - Advances in Experimental Medicine And Biology

SN - 0065-2598

ER -

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