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Photo‐biocatalytic One‐Pot Cascades for the Enantioselective Synthesis of 1,3‐Mercaptoalkanol Volatile Sulfur Compounds

Research output: Contribution to journalArticle

Kate Lauder, Anita Toscani, Yuyin Qi, Jesmine Lim, Simon J. Charnock, Krupa Korah, Daniele Castagnolo

Original languageEnglish
JournalANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume57
Issue number20
DOIs
Published14 May 2018

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Abstract

The synthesis of enantiomerically pure 1,3‐mercaptoalkanol volatile sulfur compounds through a one‐pot photo‐biocatalytic cascade reaction is described. Two new KRED biocatalysts with opposite enantioselectivity were discovered and proved to be efficient on a wide range of substrates. The one‐pot cascade reaction combining photocatalytic thio‐Michael addition with biocatalytic ketoreduction in an aqueous medium provides a green and sustainable approach to enantiomerically pure 1,3‐mercaptoalkanols in high yields with excellent enantioselectivity.

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