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Physical exercise-related endophenotypes in anorexia nervosa

Research output: Contribution to journalArticlepeer-review

Laura Di Lodovico, Hanna Hatteea, Céline Couton, Philibert Duriez, Janet Treasure, Philip Gorwood

Original languageEnglish
Pages (from-to)1181-1188
Number of pages8
JournalInternational Journal of Eating Disorders
Volume54
Issue number7
DOIs
Accepted/In press2021
PublishedJul 2021

Bibliographical note

Funding Information: Laura Di Lodovico and Hanna Hatteea equally contributed to the realization of this article. This study received a grant research from the “Fondation de l'Avenir” (Grant number: AP‐RMA‐16‐040). Janet Treasure acknowledges financial support from the National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health award to the South London and Maudsley NHS Foundation Trust and the Institute of Psychiatry, King's College London. Publisher Copyright: © 2021 Wiley Periodicals LLC. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Background: The persistence of physical exercise in anorexia nervosa (AN) despite underweight and its maintaining factors are poorly understood. The aim of this study was to explore the attitudes toward physical exercise and its effects on emotions, cognitive functioning, and body image perception in patients with AN, and to search for exercise-related endophenotypes of the pathology. Methods: Physical exercise dependence, quantity, and dysregulation were assessed by the Exercise Dependence Scale (EDS), the Godin Leisure Time Exercise Questionnaire (GLTEQ) and a standardized effort test in 88 patients with AN, 30 unaffected relatives and 89 healthy controls. Changes in positive and negative affect, cognitive rigidity, and body image distortion were measured before and after the effort test in the three groups. Results: Patients with AN had higher scores on the EDS and the GLTEQ and used more effort in the standardized effort test. These three measures of physical exercise correlated with negative emotions at baseline. After the effort test, patients with AN had marked emotional improvement, a moderate increase in body image distortion and a small increase in cognitive rigidity compared to HC. Unaffected relatives also had a significant postexercise increase of positive emotion. Discussion: The mood-related drive for physical exercise has the characteristics of an endophenotype of the disorder. Excessive and driven physical exercise may be state-associated features of AN, driven by the positive effect on emotional wellbeing.

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