Physical rehabilitation interventions for adult patients with critical illness across the continuum of recovery: An overview of systematic reviews protocol

Bronwen Connolly*, Brenda O'Neill, Lisa Salisbury, Kathryn McDowell, Bronagh Blackwood, Nicholas Hart, Michael Grocott, Stephen Brett, Timothy Walsh, David Griffith, Stephen Shepherd, Judith Merriweather, Nazir Lone, Simon Baudouin, Stephen Bonner, Kathryn McDowell, Dorothy Wade, Natalie Pattison, Danielle Bear, Sallie LambRebecca Cusack, Daniel F. McAuley, Robert Hatch, David Parkin, M. Mark Foster, Laura PriceL., Liesl Wandrag, Pamela Ramsay

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background: Patients admitted to the intensive care unit with critical illness often experience significant physical impairments, which typically persist for many years following resolution of the original illness. Physical rehabilitation interventions that enhance restoration of physical function have been evaluated across the continuum of recovery following critical illness including within the intensive care unit, following discharge to the ward and beyond hospital discharge. Multiple systematic reviews have been published appraising the expanding evidence investigating these physical rehabilitation interventions, although there appears to be variability in review methodology and quality. We aim to conduct an overview of existing systematic reviews of physical rehabilitation interventions for adult intensive care patients across the continuum of recovery. Methods/design: This protocol has been developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) guidelines. We will search the Cochrane Systematic Review Database, Database of Abstracts of Reviews of Effectiveness, Cochrane Central Register of Controlled Trials, MEDLINE, Excerpta Medica Database and Cumulative Index to Nursing and Allied Health Literature databases. We will include systematic reviews of randomised controlled trials of adult patients, admitted to the intensive care unit and who have received physical rehabilitation interventions at any time point during their recovery. Data extraction will include systematic review aims and rationale, study types, populations, interventions, comparators, outcomes and quality appraisal method. Primary outcomes of interest will focus on findings reflecting recovery of physical function. Quality of reporting and methodological quality will be appraised using the PRISMA checklist and the Assessment of Multiple Systematic Reviews tool. Discussion: We anticipate the findings from this novel overview of systematic reviews will contribute to the synthesis and interpretation of existing evidence regarding physical rehabilitation interventions and physical recovery in post-critical illness patients across the continuum of recovery. Systematic review registration: PROSPERO CRD42015001068.

Original languageEnglish
Article number130
Number of pages6
JournalSystematic Reviews
Issue number1
Publication statusPublished - 29 Sept 2015


  • Critical illness
  • Physical rehabilitation
  • Quality
  • Recovery
  • Systematic review


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