TY - JOUR
T1 - Physiology and endocrinology of zinc accumulation during the female squirrelfish reproductive cycle
AU - Thompson, E D
AU - Mayer, G D
AU - Balesaria, S
AU - Glover, C N
AU - Walsh, P J
AU - Hogstrand, C
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Females of the squirrelfish family (Holocentridae) accumulate higher levels of hepatic zinc than any other studied animal. This accumulation is accompanied by high expression of the zinc-binding protein, metallothionein (MT), and is strongly correlated to the onset of sexual maturity. In an attempt to further characterize the timeframe of this accumulation, and to possibly discern any potential mediators, we examined the physiology and endocrinology of the yearly reproductive cycle of mature female squirrelfish. There are two separate reproductive events during the year in December-January and again in March-April, as evidenced by peaks in ovarian growth, VTG production, steroid levels, zinc accumulation and redistribution. Increased hepatic zinc seems to be preceded by a necessary increase in MT, but this was not clearly correlated to plasma 17beta-estradiol, testosterone, or progesterone levels. The plasma zinc protein vitellogenin (VTG) is one, but probably not the predominant, vehicle for the transport of hepatic zinc to the ovary. (C) 2003 Elsevier Science Inc. All rights reserved.
AB - Females of the squirrelfish family (Holocentridae) accumulate higher levels of hepatic zinc than any other studied animal. This accumulation is accompanied by high expression of the zinc-binding protein, metallothionein (MT), and is strongly correlated to the onset of sexual maturity. In an attempt to further characterize the timeframe of this accumulation, and to possibly discern any potential mediators, we examined the physiology and endocrinology of the yearly reproductive cycle of mature female squirrelfish. There are two separate reproductive events during the year in December-January and again in March-April, as evidenced by peaks in ovarian growth, VTG production, steroid levels, zinc accumulation and redistribution. Increased hepatic zinc seems to be preceded by a necessary increase in MT, but this was not clearly correlated to plasma 17beta-estradiol, testosterone, or progesterone levels. The plasma zinc protein vitellogenin (VTG) is one, but probably not the predominant, vehicle for the transport of hepatic zinc to the ovary. (C) 2003 Elsevier Science Inc. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=0038278659&partnerID=8YFLogxK
U2 - 10.1016/S1095-6433(03)00015-1
DO - 10.1016/S1095-6433(03)00015-1
M3 - Article
SN - 1531-4322
VL - 134
SP - 819
EP - 828
JO - Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
JF - Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
IS - 4
ER -