Abstract
Microarray analysis has provided a new understanding of pineal function by identifying genes that are highly expressed in this tissue relative to other tissues and also by identifying over 600 genes that are expressed on a 24-h schedule. This effort has highlighted surprising similarity to the retina and has provided reason to explore new avenues of study including intracellular signaling, signal transduction, transcriptional cascades, thyroid/retinoic acid hormone signaling, metal biology, RNA splicing, and the role the pineal gland plays in the immune/inflammation response. The new foundation that microarray analysis has provided will broadly support future research on pineal function. Published by Elsevier Ireland Ltd.
Original language | English |
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Pages (from-to) | 170 - 183 |
Number of pages | 14 |
Journal | Molecular and Cellular Endocrinology |
Volume | 314 |
Issue number | 2 |
DOIs | |
Publication status | Published - 27 Jan 2010 |
Event | Summer Neuropeptide Conference/5th International Symposium on Signal Transduction in Health and Disease (STADY V) - Tel Aviv, Israel Duration: 22 Oct 2008 → 24 Oct 2008 |