Despite extensive research, the pathophysiology and prevention of pre-eclampsia remain elusive, diagnosis is challenging, and pre-eclampsia remains associated with adverse maternal and perinatal outcomes. Angiogenic biomarkers, including placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1), have been identified as valuable biomarkers for preterm pre-eclampsia, accelerating diagnosis and reducing maternal adverse outcomes by risk stratification, with enhanced surveillance for high-risk women. PlGF-based testing is increasingly being implemented in clinical practice in several countries. This review provides healthcare providers with an understanding of the evidence for PlGF-based testing and describes the practicalities and challenges to implementation. Tweetable abstract: Placental growth factor in pre-eclampsia: evidence and implementation of testing.
|Number of pages||8|
|Journal||BJOG: An International Journal of Obstetrics and Gynaecology|
|Publication status||Published - Dec 2020|
- Angiogenic biomarkers
- placental growth factor
- soluble fms-like tyrosine kinase 1