Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus: • Endocrine & Metabolic Diseases • Gastrointestinal

Sian Simpson; Lorna Smith; James Bowe

doi:10.1016/j.coph.2018.08.004

Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus: • Endocrine & Metabolic Diseases • Gastrointestinal

Sian Simpson, Lorna Smith, James Bowe

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Abstract

Pregnancy involves a progressive increase in insulin resistance and the β-cells must adapt to compensate and prevent gestational diabetes (GDM). In this review we discuss the evidence for placental peptides, including placental lactogen, hepatocyte growth factor, adiponectin and leptin, playing a role in the islet adaptation to pregnancy. The difficulties of translating data from rodent models into human pregnancy are covered and we summarise studies investigating associations between serum placental peptides and GDM risk. In conclusion, current data support important roles for placental peptides interacting to support β-cells during pregnancy, however mechanisms involved in humans are unclear. Further work in humans is required, but placental peptides have clinical potential from both a diagnostic and therapeutic perspective.

Original language	English
Pages (from-to)	59-65
Number of pages	7
Journal	Current Opinion in Pharmacology
Volume	43
Early online date	7 Sept 2018
DOIs	https://doi.org/10.1016/j.coph.2018.08.004
Publication status	Published - Dec 2018

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Placental peptides regulating islet_SIMPSON_Firstonline7September2018_GREEN AAM (CC BY-NC-ND)Final published version, 340 KBLicence: CC BY-NC-ND

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abstract = "Pregnancy involves a progressive increase in insulin resistance and the β-cells must adapt to compensate and prevent gestational diabetes (GDM). In this review we discuss the evidence for placental peptides, including placental lactogen, hepatocyte growth factor, adiponectin and leptin, playing a role in the islet adaptation to pregnancy. The difficulties of translating data from rodent models into human pregnancy are covered and we summarise studies investigating associations between serum placental peptides and GDM risk. In conclusion, current data support important roles for placental peptides interacting to support β-cells during pregnancy, however mechanisms involved in humans are unclear. Further work in humans is required, but placental peptides have clinical potential from both a diagnostic and therapeutic perspective.",

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Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus: • Endocrine & Metabolic Diseases • Gastrointestinal

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