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Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus: • Endocrine & Metabolic Diseases • Gastrointestinal

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Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus : • Endocrine & Metabolic Diseases • Gastrointestinal. / Simpson, Sian; Smith, Lorna; Bowe, James.

In: Current Opinion in Pharmacology, Vol. 43, 12.2018, p. 59-65.

Research output: Contribution to journalArticle

Harvard

Simpson, S, Smith, L & Bowe, J 2018, 'Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus: • Endocrine & Metabolic Diseases • Gastrointestinal', Current Opinion in Pharmacology, vol. 43, pp. 59-65. https://doi.org/10.1016/j.coph.2018.08.004

APA

Simpson, S., Smith, L., & Bowe, J. (2018). Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus: • Endocrine & Metabolic Diseases • Gastrointestinal. Current Opinion in Pharmacology, 43, 59-65. https://doi.org/10.1016/j.coph.2018.08.004

Vancouver

Simpson S, Smith L, Bowe J. Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus: • Endocrine & Metabolic Diseases • Gastrointestinal. Current Opinion in Pharmacology. 2018 Dec;43:59-65. https://doi.org/10.1016/j.coph.2018.08.004

Author

Simpson, Sian ; Smith, Lorna ; Bowe, James. / Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus : • Endocrine & Metabolic Diseases • Gastrointestinal. In: Current Opinion in Pharmacology. 2018 ; Vol. 43. pp. 59-65.

Bibtex Download

@article{386e6d424c63400e8a28b1852378becf,
title = "Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus: • Endocrine & Metabolic Diseases • Gastrointestinal",
abstract = "Pregnancy involves a progressive increase in insulin resistance and the β-cells must adapt to compensate and prevent gestational diabetes (GDM). In this review we discuss the evidence for placental peptides, including placental lactogen, hepatocyte growth factor, adiponectin and leptin, playing a role in the islet adaptation to pregnancy. The difficulties of translating data from rodent models into human pregnancy are covered and we summarise studies investigating associations between serum placental peptides and GDM risk. In conclusion, current data support important roles for placental peptides interacting to support β-cells during pregnancy, however mechanisms involved in humans are unclear. Further work in humans is required, but placental peptides have clinical potential from both a diagnostic and therapeutic perspective.",
author = "Sian Simpson and Lorna Smith and James Bowe",
year = "2018",
month = dec,
doi = "10.1016/j.coph.2018.08.004",
language = "English",
volume = "43",
pages = "59--65",
journal = "Current Opinion in Pharmacology",
issn = "1471-4892",
publisher = "Elsevier BV",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus

T2 - • Endocrine & Metabolic Diseases • Gastrointestinal

AU - Simpson, Sian

AU - Smith, Lorna

AU - Bowe, James

PY - 2018/12

Y1 - 2018/12

N2 - Pregnancy involves a progressive increase in insulin resistance and the β-cells must adapt to compensate and prevent gestational diabetes (GDM). In this review we discuss the evidence for placental peptides, including placental lactogen, hepatocyte growth factor, adiponectin and leptin, playing a role in the islet adaptation to pregnancy. The difficulties of translating data from rodent models into human pregnancy are covered and we summarise studies investigating associations between serum placental peptides and GDM risk. In conclusion, current data support important roles for placental peptides interacting to support β-cells during pregnancy, however mechanisms involved in humans are unclear. Further work in humans is required, but placental peptides have clinical potential from both a diagnostic and therapeutic perspective.

AB - Pregnancy involves a progressive increase in insulin resistance and the β-cells must adapt to compensate and prevent gestational diabetes (GDM). In this review we discuss the evidence for placental peptides, including placental lactogen, hepatocyte growth factor, adiponectin and leptin, playing a role in the islet adaptation to pregnancy. The difficulties of translating data from rodent models into human pregnancy are covered and we summarise studies investigating associations between serum placental peptides and GDM risk. In conclusion, current data support important roles for placental peptides interacting to support β-cells during pregnancy, however mechanisms involved in humans are unclear. Further work in humans is required, but placental peptides have clinical potential from both a diagnostic and therapeutic perspective.

UR - http://www.scopus.com/inward/record.url?scp=85052927715&partnerID=8YFLogxK

U2 - 10.1016/j.coph.2018.08.004

DO - 10.1016/j.coph.2018.08.004

M3 - Article

VL - 43

SP - 59

EP - 65

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

SN - 1471-4892

ER -

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