Plasma exchange in the intensive care unit: a narrative review

the Nine-I Investigators

doi:10.1007/s00134-022-06793-z

Plasma exchange in the intensive care unit: a narrative review

the Nine-I Investigators

Inflammation Biology

Research output: Contribution to journal › Review article › peer-review

58 Citations (Scopus)

Abstract

In this narrative review, we discuss the relevant issues of therapeutic plasma exchange (TPE) in critically ill patients. For many conditions, the optimal indication, device type, frequency, duration, type of replacement fluid and criteria for stopping TPE are uncertain. TPE is a potentially lifesaving but also invasive procedure with risk of adverse events and complications and requires close monitoring by experienced teams. In the intensive care unit (ICU), the indications for TPE can be divided into (1) absolute, well-established, and evidence-based, for which TPE is recognized as first-line therapy, (2) relative, for which TPE is a recognized second-line treatment (alone or combined) and (3) rescue therapy, where TPE is used with a limited or theoretical evidence base. New indications are emerging and ongoing knowledge gaps, notably regarding the use of TPE during critical illness, support the establishment of a TPE registry dedicated to intensive care medicine.

Original language	English
Pages (from-to)	1382-1396
Number of pages	15
Journal	Intensive Care Medicine
Volume	48
Issue number	10
DOIs	https://doi.org/10.1007/s00134-022-06793-z
Publication status	Published - Oct 2022

Keywords

Intensive care units
Patient care team
Plasma exchange
Plasmapheresis
State-of-the-art review

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10.1007/s00134-022-06793-z

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@article{e7e1d7f22e2346fbbb7a57a3f52ac934,

title = "Plasma exchange in the intensive care unit: a narrative review",

abstract = "In this narrative review, we discuss the relevant issues of therapeutic plasma exchange (TPE) in critically ill patients. For many conditions, the optimal indication, device type, frequency, duration, type of replacement fluid and criteria for stopping TPE are uncertain. TPE is a potentially lifesaving but also invasive procedure with risk of adverse events and complications and requires close monitoring by experienced teams. In the intensive care unit (ICU), the indications for TPE can be divided into (1) absolute, well-established, and evidence-based, for which TPE is recognized as first-line therapy, (2) relative, for which TPE is a recognized second-line treatment (alone or combined) and (3) rescue therapy, where TPE is used with a limited or theoretical evidence base. New indications are emerging and ongoing knowledge gaps, notably regarding the use of TPE during critical illness, support the establishment of a TPE registry dedicated to intensive care medicine.",

keywords = "Intensive care units, Patient care team, Plasma exchange, Plasmapheresis, State-of-the-art review",

author = "{the Nine-I Investigators} and Bauer, {Philippe R.} and Marlies Ostermann and Lene Russell and Chiara Robba and Sascha David and Ferreyro, {Bruno L.} and Joan Cid and Pedro Castro and Juffermans, {Nicole P.} and Luca Montini and Tasneem Pirani and {Van De Louw}, Andry and Nathan Nielsen and Julia Wendon and Brignier, {Anne C.} and Miet Schetz and Kielstein, {Jan T.} and Winters, {Jeffrey L.} and Elie Azoulay and Nina Buchtele and Thomas Staudinger and Gottfried Heinz and G{\"u}rkan Seng{\"o}lge and Christian Zauner and Peter Jaksch and Karin Amrein and Peter Schellongowski and Thomas Staudinger and Meert, {Anne Pascale} and Dominique Benoit and Taccone, {Fabio Silvio} and {de Moraes}, {Ana Paula Pierre} and William Viana and Guilliana Moralez and Thiago Lishoa and Marcio Soares and Jorge Salluh and Silva, {U. V.} and Sumech Shah and Sangeeta Mehta and Laveena Munshi and Balik Martin and Karvunidis Thomas and Katerina Rusinova and Jonas Nelsen and Moeller, {Ann M.} and Anders Perner and Sylvest Meyhoff and Bukan, {Ramin Brandt} and Nielsen, {Lene B.}",

note = "Funding Information: The Nine-I Investigators: Austria: Nina Buchtele, Department of Medicine I, Vienna; Thomas Staudinger, Department of Medicine I, Vienna; Gottfried Heinz, Department of Medicine II, Vienna; G{\"u}rkan Seng{\"o}lge, Department of Medicine III, Vienna; Christian Zauner, Department of Medicine III, Vienna ; Peter Jaksch, Department of Thoracic Surgery, Vienna; Karin Amrein, Department of Internal Medicine, Graz; Peter Schellongowski; Department of Medicine I, Medical University of Vienna, Vienna, Austria; Thomas Staudinger; Department of Medicine I, Medical University of Vienna, Vienna. Belgium: Anne-Pascale Meert, Institut Jules Bordet, Brussels; Dominique Benoit, Ghent University Hospital, Ghent Publisher Copyright: {\textcopyright} 2022, Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2022",

month = oct,

doi = "10.1007/s00134-022-06793-z",

language = "English",

volume = "48",

pages = "1382--1396",

journal = "Intensive Care Medicine",

issn = "0342-4642",

publisher = "Springer Verlag",

number = "10",

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T1 - Plasma exchange in the intensive care unit

T2 - a narrative review

AU - the Nine-I Investigators

AU - Bauer, Philippe R.

AU - Ostermann, Marlies

AU - Russell, Lene

AU - Robba, Chiara

AU - David, Sascha

AU - Ferreyro, Bruno L.

AU - Cid, Joan

AU - Castro, Pedro

AU - Juffermans, Nicole P.

AU - Montini, Luca

AU - Pirani, Tasneem

AU - Van De Louw, Andry

AU - Nielsen, Nathan

AU - Wendon, Julia

AU - Brignier, Anne C.

AU - Schetz, Miet

AU - Kielstein, Jan T.

AU - Winters, Jeffrey L.

AU - Azoulay, Elie

AU - Buchtele, Nina

AU - Staudinger, Thomas

AU - Heinz, Gottfried

AU - Sengölge, Gürkan

AU - Zauner, Christian

AU - Jaksch, Peter

AU - Amrein, Karin

AU - Schellongowski, Peter

AU - Staudinger, Thomas

AU - Meert, Anne Pascale

AU - Benoit, Dominique

AU - Taccone, Fabio Silvio

AU - de Moraes, Ana Paula Pierre

AU - Viana, William

AU - Moralez, Guilliana

AU - Lishoa, Thiago

AU - Soares, Marcio

AU - Salluh, Jorge

AU - Silva, U. V.

AU - Shah, Sumech

AU - Mehta, Sangeeta

AU - Munshi, Laveena

AU - Martin, Balik

AU - Thomas, Karvunidis

AU - Rusinova, Katerina

AU - Nelsen, Jonas

AU - Moeller, Ann M.

AU - Perner, Anders

AU - Meyhoff, Sylvest

AU - Bukan, Ramin Brandt

AU - Nielsen, Lene B.

N1 - Funding Information: The Nine-I Investigators: Austria: Nina Buchtele, Department of Medicine I, Vienna; Thomas Staudinger, Department of Medicine I, Vienna; Gottfried Heinz, Department of Medicine II, Vienna; Gürkan Sengölge, Department of Medicine III, Vienna; Christian Zauner, Department of Medicine III, Vienna ; Peter Jaksch, Department of Thoracic Surgery, Vienna; Karin Amrein, Department of Internal Medicine, Graz; Peter Schellongowski; Department of Medicine I, Medical University of Vienna, Vienna, Austria; Thomas Staudinger; Department of Medicine I, Medical University of Vienna, Vienna. Belgium: Anne-Pascale Meert, Institut Jules Bordet, Brussels; Dominique Benoit, Ghent University Hospital, Ghent Publisher Copyright: © 2022, Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2022/10

Y1 - 2022/10

N2 - In this narrative review, we discuss the relevant issues of therapeutic plasma exchange (TPE) in critically ill patients. For many conditions, the optimal indication, device type, frequency, duration, type of replacement fluid and criteria for stopping TPE are uncertain. TPE is a potentially lifesaving but also invasive procedure with risk of adverse events and complications and requires close monitoring by experienced teams. In the intensive care unit (ICU), the indications for TPE can be divided into (1) absolute, well-established, and evidence-based, for which TPE is recognized as first-line therapy, (2) relative, for which TPE is a recognized second-line treatment (alone or combined) and (3) rescue therapy, where TPE is used with a limited or theoretical evidence base. New indications are emerging and ongoing knowledge gaps, notably regarding the use of TPE during critical illness, support the establishment of a TPE registry dedicated to intensive care medicine.

AB - In this narrative review, we discuss the relevant issues of therapeutic plasma exchange (TPE) in critically ill patients. For many conditions, the optimal indication, device type, frequency, duration, type of replacement fluid and criteria for stopping TPE are uncertain. TPE is a potentially lifesaving but also invasive procedure with risk of adverse events and complications and requires close monitoring by experienced teams. In the intensive care unit (ICU), the indications for TPE can be divided into (1) absolute, well-established, and evidence-based, for which TPE is recognized as first-line therapy, (2) relative, for which TPE is a recognized second-line treatment (alone or combined) and (3) rescue therapy, where TPE is used with a limited or theoretical evidence base. New indications are emerging and ongoing knowledge gaps, notably regarding the use of TPE during critical illness, support the establishment of a TPE registry dedicated to intensive care medicine.

KW - Intensive care units

KW - Patient care team

KW - Plasma exchange

KW - Plasmapheresis

KW - State-of-the-art review

UR - http://www.scopus.com/inward/record.url?scp=85136066400&partnerID=8YFLogxK

U2 - 10.1007/s00134-022-06793-z

DO - 10.1007/s00134-022-06793-z

M3 - Review article

C2 - 35960275

AN - SCOPUS:85136066400

SN - 0342-4642

VL - 48

SP - 1382

EP - 1396

JO - Intensive Care Medicine

JF - Intensive Care Medicine

IS - 10

ER -

Plasma exchange in the intensive care unit: a narrative review

Abstract

Keywords

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