Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: A double-blind randomized controlled trial

Geoffrey Istas, Rodrigo P. Feliciano, Timon Weber, Rocio Garcia-Villalba, Francisco Tomas-Barberan, Christian Heiss, Ana Rodriguez-Mateos

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)
355 Downloads (Pure)

Abstract

Raspberries are a rich source of ellagitannins and anthocyanins. The aim of this work was to investigate whether raspberry consumption can improve vascular function and to understand which phenolic metabolites may be responsible for the effects. A 3 arm double-blind randomized controlled crossover human intervention trial was conducted in 10 healthy males. Flow-mediated dilation (FMD) was measured at baseline, 2 h, and 24 h post-consumption of 200 g and 400 g of red raspberries containing 201 or 403 mg of total (poly)phenols, or a matched control drink. Raspberry (poly)phenol metabolites were analyzed in plasma and urine by UPLC-QTOF mass spectrometry using authentic standards. Significant improvements in FMD were observed at 2 h (1.6% (95%CI 1.2, 1.9) and 1.2% (95% CI 0.8, 1.5)) and 24 h (1.0% (95% CI 0.6, 1.2) and 0.7% (95%CI 0.2, 0.9)) post-consumption of the 200 and 400 g raspberry drinks as compared to control, respectively. Plasma ellagic acid, urolithin A-3-glucuronide and urolithin A-sulfate correlated with the improvements in FMD at 2 and 24 h post consumption, respectively. Consumption of dietary achievable amounts of red raspberries acutely improves endothelial function up to 24 h and ellagitannins may be responsible for the observed effect.
Original languageEnglish
Pages (from-to)43-51
Number of pages9
JournalArchives of biochemistry and biophysics
Volume651
Early online date24 May 2018
DOIs
Publication statusE-pub ahead of print - 24 May 2018

Keywords

  • Raspberries
  • Endothelial function
  • (Poly)phenols
  • Ellagittanins
  • Urolithins

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