Polyoxometalate clusters integrated into peptide chains and as inorganic amino acids: Solution- and solid-phase approaches

C. Yvon, A.J. Surman, M. Hutin, J. Alex, B.O. Smith, D.-L. Long, L. Cronin

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)

Abstract

General synthetic methods for the grafting of peptide chains onto polyoxometalate clusters by the use of general activated precursors have been developed. Using a solution‐phase approach, pre‐synthesized peptides can be grafted to a metal oxide cluster to produce hybrids of unprecedented scale (up to 30 residues). An adapted solid‐phase method allows the incorporation of these clusters, which may be regarded as novel hybrid unnatural amino acids, during the peptide synthesis itself. These methods may open the way for the automated synthesis of peptides and perhaps even proteins that contain “inorganic” amino acids.
Original languageEnglish
Pages (from-to)3336-3341
Number of pages6
JournalANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume53
Issue number13
Early online date12 Mar 2014
DOIs
Publication statusPublished - 24 Mar 2014

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