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Polysubstance use and misuse or abuse of prescription opioid analgesics: A multi-level analysis of international data

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Polysubstance use and misuse or abuse of prescription opioid analgesics : A multi-level analysis of international data. / Morley, Katherine I; Ferris, Jason; Winstock, Adam R; Lynskey, Michael T.

In: Pain, Vol. 158, No. 6, 2017, p. 1138-1144.

Research output: Contribution to journalArticle

Harvard

Morley, KI, Ferris, J, Winstock, AR & Lynskey, MT 2017, 'Polysubstance use and misuse or abuse of prescription opioid analgesics: A multi-level analysis of international data', Pain, vol. 158, no. 6, pp. 1138-1144. https://doi.org/10.1097/j.pain.0000000000000892

APA

Morley, K. I., Ferris, J., Winstock, A. R., & Lynskey, M. T. (2017). Polysubstance use and misuse or abuse of prescription opioid analgesics: A multi-level analysis of international data. Pain, 158(6), 1138-1144. https://doi.org/10.1097/j.pain.0000000000000892

Vancouver

Morley KI, Ferris J, Winstock AR, Lynskey MT. Polysubstance use and misuse or abuse of prescription opioid analgesics: A multi-level analysis of international data. Pain. 2017;158(6):1138-1144. https://doi.org/10.1097/j.pain.0000000000000892

Author

Morley, Katherine I ; Ferris, Jason ; Winstock, Adam R ; Lynskey, Michael T. / Polysubstance use and misuse or abuse of prescription opioid analgesics : A multi-level analysis of international data. In: Pain. 2017 ; Vol. 158, No. 6. pp. 1138-1144.

Bibtex Download

@article{8b2055b4b65c4719a9ee28000668d299,
title = "Polysubstance use and misuse or abuse of prescription opioid analgesics: A multi-level analysis of international data",
abstract = "Increasing mortality and morbidity associated with opioid analgesics has led to concerns about their misuse and abuse, even when obtained via a prescription. These concerns have been most pronounced in the United States of America (USA), but limited data make it difficult to determine whether it is a problem in other countries. We investigated opioid analgesic misuse and abuse in participants from the Global Drug Survey 2015 resident in the USA (N=1,334), United Kingdom (N=1,199), France (N=1,258), Germany (N=866), and Australia (N=1,013) who had used at least one prescription opioid analgesic medication in the past year. We also investigated the relationship with polysubstance use, one of the most consistent predictors of problematic opioid analgesic use. Data included misuse and abuse of codeine, hydrocodone, oxycontin, and tramadol; ability to obtain a prescription; different sources for obtaining drugs; and past year use of benzodiazepines and illicit drugs. In multilevel models country of residence accounted for less than 3{\%} of the variance in opioid analgesic misuse or abuse. Adjusting for country of residence and sociodemographic factors, use of illicit drugs and benzodiazepines was associated with four-fold greater odds of misuse (OR 4.36, 95{\%} CI 3.29-5.93) and six-fold greater odds of abuse compared to not using either drug (OR 6.49, 95{\%} CI 4.0-10.48), although the strength of the association with abuse varied by country. Misuse and abuse by those prescribed opioid analgesics appears to be a problem that is not limited to the USA and warrants attention on an international scale.",
author = "Morley, {Katherine I} and Jason Ferris and Winstock, {Adam R} and Lynskey, {Michael T}",
year = "2017",
doi = "10.1097/j.pain.0000000000000892",
language = "English",
volume = "158",
pages = "1138--1144",
journal = "Pain",
issn = "0304-3959",
publisher = "ELSEVIER SCIENCE BV",
number = "6",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Polysubstance use and misuse or abuse of prescription opioid analgesics

T2 - A multi-level analysis of international data

AU - Morley, Katherine I

AU - Ferris, Jason

AU - Winstock, Adam R

AU - Lynskey, Michael T

PY - 2017

Y1 - 2017

N2 - Increasing mortality and morbidity associated with opioid analgesics has led to concerns about their misuse and abuse, even when obtained via a prescription. These concerns have been most pronounced in the United States of America (USA), but limited data make it difficult to determine whether it is a problem in other countries. We investigated opioid analgesic misuse and abuse in participants from the Global Drug Survey 2015 resident in the USA (N=1,334), United Kingdom (N=1,199), France (N=1,258), Germany (N=866), and Australia (N=1,013) who had used at least one prescription opioid analgesic medication in the past year. We also investigated the relationship with polysubstance use, one of the most consistent predictors of problematic opioid analgesic use. Data included misuse and abuse of codeine, hydrocodone, oxycontin, and tramadol; ability to obtain a prescription; different sources for obtaining drugs; and past year use of benzodiazepines and illicit drugs. In multilevel models country of residence accounted for less than 3% of the variance in opioid analgesic misuse or abuse. Adjusting for country of residence and sociodemographic factors, use of illicit drugs and benzodiazepines was associated with four-fold greater odds of misuse (OR 4.36, 95% CI 3.29-5.93) and six-fold greater odds of abuse compared to not using either drug (OR 6.49, 95% CI 4.0-10.48), although the strength of the association with abuse varied by country. Misuse and abuse by those prescribed opioid analgesics appears to be a problem that is not limited to the USA and warrants attention on an international scale.

AB - Increasing mortality and morbidity associated with opioid analgesics has led to concerns about their misuse and abuse, even when obtained via a prescription. These concerns have been most pronounced in the United States of America (USA), but limited data make it difficult to determine whether it is a problem in other countries. We investigated opioid analgesic misuse and abuse in participants from the Global Drug Survey 2015 resident in the USA (N=1,334), United Kingdom (N=1,199), France (N=1,258), Germany (N=866), and Australia (N=1,013) who had used at least one prescription opioid analgesic medication in the past year. We also investigated the relationship with polysubstance use, one of the most consistent predictors of problematic opioid analgesic use. Data included misuse and abuse of codeine, hydrocodone, oxycontin, and tramadol; ability to obtain a prescription; different sources for obtaining drugs; and past year use of benzodiazepines and illicit drugs. In multilevel models country of residence accounted for less than 3% of the variance in opioid analgesic misuse or abuse. Adjusting for country of residence and sociodemographic factors, use of illicit drugs and benzodiazepines was associated with four-fold greater odds of misuse (OR 4.36, 95% CI 3.29-5.93) and six-fold greater odds of abuse compared to not using either drug (OR 6.49, 95% CI 4.0-10.48), although the strength of the association with abuse varied by country. Misuse and abuse by those prescribed opioid analgesics appears to be a problem that is not limited to the USA and warrants attention on an international scale.

U2 - 10.1097/j.pain.0000000000000892

DO - 10.1097/j.pain.0000000000000892

M3 - Article

C2 - 28267061

VL - 158

SP - 1138

EP - 1144

JO - Pain

JF - Pain

SN - 0304-3959

IS - 6

ER -

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