Poor outcome and prolonged persistence of SARS-CoV-2 RNA in COVID-19 patients with haematological malignancies; King's College Hospital experience

Vallari Shah; Thinzar Ko Ko; Mark Zuckerman; Jennifer Vidler; Sobia Sharif; Varun Mehra; Shreyans Gandhi; Andrea Kuhnl; Deborah Yallop; Daniele Avenoso; Carmel Rice; Robin Sanderson; Anita Sarma; Judith Marsh; Hugues de Lavallade; Pramila Krishnamurthy; Piers Patten; Reuben Benjamin; Victoria Potter; M Mansour Ceesay; Ghulam J Mufti; Sam Norton; Antonio Pagliuca; James Galloway; Austin G Kulasekararaj

doi:10.1111/bjh.16935

Poor outcome and prolonged persistence of SARS-CoV-2 RNA in COVID-19 patients with haematological malignancies; King's College Hospital experience

Vallari Shah, Thinzar Ko Ko, Mark Zuckerman, Jennifer Vidler, Sobia Sharif, Varun Mehra, Shreyans Gandhi, Andrea Kuhnl, Deborah Yallop, Daniele Avenoso, Carmel Rice, Robin Sanderson, Anita Sarma, Judith Marsh, Hugues de Lavallade, Pramila Krishnamurthy, Piers Patten, Reuben Benjamin, Victoria Potter, M Mansour CeesayGhulam J Mufti, Sam Norton, Antonio Pagliuca, James Galloway, Austin G Kulasekararaj

Research output: Contribution to journal › Letter

84 Citations (Scopus)

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), emerged at the end of 2019 and caused an infection named COVID-19 (Guan, Ni et al. 2020). Patients with compromised immune systems are at increased risk of complications but this risk is not precisely defined (Liang, Guan et al. 2020). Although age, gender, comorbidities and ethnicity are risk factors for adverse outcomes (Huang, Wang et al. 2020), various pre-existing conditions, including haematological cancers, have also been reported to correlate with poor outcomes (Aries, Davies et al. 2020, He, Chen et al. 2020, Malard, Genthon et al. 2020, Martin-Moro, Marquet et al. 2020, medRxiv 2020).

Original language	English
Pages (from-to)	e279-e282
Journal	British Journal of Haematology
Volume	190
Issue number	5
Early online date	11 Jun 2020
DOIs	https://doi.org/10.1111/bjh.16935
Publication status	Published - 1 Sept 2020

Keywords

COVID-19
SARS-CoV-2
haematological malignancies
lymphoid malignancies
myeloid malignancies
stem cell transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/bjh.16935

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Shah, V., Ko Ko, T., Zuckerman, M., Vidler, J., Sharif, S., Mehra, V., Gandhi, S., Kuhnl, A., Yallop, D., Avenoso, D., Rice, C., Sanderson, R., Sarma, A., Marsh, J., de Lavallade, H., Krishnamurthy, P., Patten, P., Benjamin, R., Potter, V., ... Kulasekararaj, A. G. (2020). Poor outcome and prolonged persistence of SARS-CoV-2 RNA in COVID-19 patients with haematological malignancies; King's College Hospital experience. British Journal of Haematology, 190(5), e279-e282. https://doi.org/10.1111/bjh.16935

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title = "Poor outcome and prolonged persistence of SARS-CoV-2 RNA in COVID-19 patients with haematological malignancies; King's College Hospital experience",

abstract = "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), emerged at the end of 2019 and caused an infection named COVID-19 (Guan, Ni et al. 2020). Patients with compromised immune systems are at increased risk of complications but this risk is not precisely defined (Liang, Guan et al. 2020). Although age, gender, comorbidities and ethnicity are risk factors for adverse outcomes (Huang, Wang et al. 2020), various pre-existing conditions, including haematological cancers, have also been reported to correlate with poor outcomes (Aries, Davies et al. 2020, He, Chen et al. 2020, Malard, Genthon et al. 2020, Martin-Moro, Marquet et al. 2020, medRxiv 2020).",

keywords = "COVID-19, SARS-CoV-2, haematological malignancies, lymphoid malignancies, myeloid malignancies, stem cell transplantation",

author = "Vallari Shah and {Ko Ko}, Thinzar and Mark Zuckerman and Jennifer Vidler and Sobia Sharif and Varun Mehra and Shreyans Gandhi and Andrea Kuhnl and Deborah Yallop and Daniele Avenoso and Carmel Rice and Robin Sanderson and Anita Sarma and Judith Marsh and {de Lavallade}, Hugues and Pramila Krishnamurthy and Piers Patten and Reuben Benjamin and Victoria Potter and Ceesay, {M Mansour} and Mufti, {Ghulam J} and Sam Norton and Antonio Pagliuca and James Galloway and Kulasekararaj, {Austin G}",

year = "2020",

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doi = "10.1111/bjh.16935",

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Shah, V, Ko Ko, T, Zuckerman, M, Vidler, J, Sharif, S, Mehra, V, Gandhi, S, Kuhnl, A, Yallop, D, Avenoso, D, Rice, C, Sanderson, R, Sarma, A, Marsh, J, de Lavallade, H, Krishnamurthy, P, Patten, P , Benjamin, R, Potter, V, Ceesay, MM, Mufti, GJ , Norton, S , Pagliuca, A , Galloway, J & Kulasekararaj, AG 2020, 'Poor outcome and prolonged persistence of SARS-CoV-2 RNA in COVID-19 patients with haematological malignancies; King's College Hospital experience', British Journal of Haematology, vol. 190, no. 5, pp. e279-e282. https://doi.org/10.1111/bjh.16935

TY - JOUR

T1 - Poor outcome and prolonged persistence of SARS-CoV-2 RNA in COVID-19 patients with haematological malignancies; King's College Hospital experience

AU - Shah, Vallari

AU - Ko Ko, Thinzar

AU - Zuckerman, Mark

AU - Vidler, Jennifer

AU - Sharif, Sobia

AU - Mehra, Varun

AU - Gandhi, Shreyans

AU - Kuhnl, Andrea

AU - Yallop, Deborah

AU - Avenoso, Daniele

AU - Rice, Carmel

AU - Sanderson, Robin

AU - Sarma, Anita

AU - Marsh, Judith

AU - de Lavallade, Hugues

AU - Krishnamurthy, Pramila

AU - Patten, Piers

AU - Benjamin, Reuben

AU - Potter, Victoria

AU - Ceesay, M Mansour

AU - Mufti, Ghulam J

AU - Norton, Sam

AU - Pagliuca, Antonio

AU - Galloway, James

AU - Kulasekararaj, Austin G

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), emerged at the end of 2019 and caused an infection named COVID-19 (Guan, Ni et al. 2020). Patients with compromised immune systems are at increased risk of complications but this risk is not precisely defined (Liang, Guan et al. 2020). Although age, gender, comorbidities and ethnicity are risk factors for adverse outcomes (Huang, Wang et al. 2020), various pre-existing conditions, including haematological cancers, have also been reported to correlate with poor outcomes (Aries, Davies et al. 2020, He, Chen et al. 2020, Malard, Genthon et al. 2020, Martin-Moro, Marquet et al. 2020, medRxiv 2020).

AB - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), emerged at the end of 2019 and caused an infection named COVID-19 (Guan, Ni et al. 2020). Patients with compromised immune systems are at increased risk of complications but this risk is not precisely defined (Liang, Guan et al. 2020). Although age, gender, comorbidities and ethnicity are risk factors for adverse outcomes (Huang, Wang et al. 2020), various pre-existing conditions, including haematological cancers, have also been reported to correlate with poor outcomes (Aries, Davies et al. 2020, He, Chen et al. 2020, Malard, Genthon et al. 2020, Martin-Moro, Marquet et al. 2020, medRxiv 2020).

KW - COVID-19

KW - SARS-CoV-2

KW - haematological malignancies

KW - lymphoid malignancies

KW - myeloid malignancies

KW - stem cell transplantation

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U2 - 10.1111/bjh.16935

DO - 10.1111/bjh.16935

M3 - Letter

C2 - 32526039

SN - 0007-1048

VL - 190

SP - e279-e282

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 5

ER -

Poor outcome and prolonged persistence of SARS-CoV-2 RNA in COVID-19 patients with haematological malignancies; King's College Hospital experience

Abstract

Keywords

UN SDGs

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