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Population DNA methylation studies in the Developmental Origins of Health and Disease DOHaD framework

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Population DNA methylation studies in the Developmental Origins of Health and Disease DOHaD framework. / Felix, Janine F.; Cecil, Charlotte.

In: Journal of Developmental Origins of Health and Disease, 13.08.2018.

Research output: Contribution to journalReview article

Harvard

Felix, JF & Cecil, C 2018, 'Population DNA methylation studies in the Developmental Origins of Health and Disease DOHaD framework', Journal of Developmental Origins of Health and Disease. https://doi.org/10.1017/S2040174418000442

APA

Felix, J. F., & Cecil, C. (2018). Population DNA methylation studies in the Developmental Origins of Health and Disease DOHaD framework. Journal of Developmental Origins of Health and Disease. https://doi.org/10.1017/S2040174418000442

Vancouver

Felix JF, Cecil C. Population DNA methylation studies in the Developmental Origins of Health and Disease DOHaD framework. Journal of Developmental Origins of Health and Disease. 2018 Aug 13. https://doi.org/10.1017/S2040174418000442

Author

Felix, Janine F. ; Cecil, Charlotte. / Population DNA methylation studies in the Developmental Origins of Health and Disease DOHaD framework. In: Journal of Developmental Origins of Health and Disease. 2018.

Bibtex Download

@article{7f458d848c3e42aca0fa3b92f2536b48,
title = "Population DNA methylation studies in the Developmental Origins of Health and Disease DOHaD framework",
abstract = "Epigenetic changes represent a potential mechanism underlying associations of early-life exposures and later-life health outcomes. Population-based cohort studies starting in early life are an attractive framework to study the role of such changes. DNA methylation is the most studied epigenetic mechanism in population research. We discuss the application of DNA methylation in early-life population studies, some recent findings, key challenges and recommendations for future research. Studies into DNA methylation within the DOHaD framework generally either explore associations between prenatal exposures and offspring DNA methylation or associations between offspring DNA methylation in early life and later health outcomes. Only few studies to date have integrated prospective exposure, epigenetic and phenotypic data in order to explicitly test the role of DNA methylation as a potential biological mediator of environmental effects on health outcomes. Population epigenetics is an emerging field which has challenges in terms of methodology and interpretation of the data. Key challenges include tissue specificity, cell type adjustment, issues of power and comparability of findings, genetic influences, and exploring causality and functional consequences. Ongoing studies are working on addressing these issues. Large collaborative efforts of prospective cohorts are emerging, with clear benefits in terms of optimizing power and use of resources, and in advancing methodology. In the future, multidisciplinary approaches, within and beyond longitudinal birth and preconception cohorts will advance this complex, but highly promising, field of research.",
author = "Felix, {Janine F.} and Charlotte Cecil",
year = "2018",
month = aug,
day = "13",
doi = "10.1017/S2040174418000442",
language = "English",
journal = "Journal of Developmental Origins of Health and Disease",
issn = "2040-1744",
publisher = "Cambridge University Press",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Population DNA methylation studies in the Developmental Origins of Health and Disease DOHaD framework

AU - Felix, Janine F.

AU - Cecil, Charlotte

PY - 2018/8/13

Y1 - 2018/8/13

N2 - Epigenetic changes represent a potential mechanism underlying associations of early-life exposures and later-life health outcomes. Population-based cohort studies starting in early life are an attractive framework to study the role of such changes. DNA methylation is the most studied epigenetic mechanism in population research. We discuss the application of DNA methylation in early-life population studies, some recent findings, key challenges and recommendations for future research. Studies into DNA methylation within the DOHaD framework generally either explore associations between prenatal exposures and offspring DNA methylation or associations between offspring DNA methylation in early life and later health outcomes. Only few studies to date have integrated prospective exposure, epigenetic and phenotypic data in order to explicitly test the role of DNA methylation as a potential biological mediator of environmental effects on health outcomes. Population epigenetics is an emerging field which has challenges in terms of methodology and interpretation of the data. Key challenges include tissue specificity, cell type adjustment, issues of power and comparability of findings, genetic influences, and exploring causality and functional consequences. Ongoing studies are working on addressing these issues. Large collaborative efforts of prospective cohorts are emerging, with clear benefits in terms of optimizing power and use of resources, and in advancing methodology. In the future, multidisciplinary approaches, within and beyond longitudinal birth and preconception cohorts will advance this complex, but highly promising, field of research.

AB - Epigenetic changes represent a potential mechanism underlying associations of early-life exposures and later-life health outcomes. Population-based cohort studies starting in early life are an attractive framework to study the role of such changes. DNA methylation is the most studied epigenetic mechanism in population research. We discuss the application of DNA methylation in early-life population studies, some recent findings, key challenges and recommendations for future research. Studies into DNA methylation within the DOHaD framework generally either explore associations between prenatal exposures and offspring DNA methylation or associations between offspring DNA methylation in early life and later health outcomes. Only few studies to date have integrated prospective exposure, epigenetic and phenotypic data in order to explicitly test the role of DNA methylation as a potential biological mediator of environmental effects on health outcomes. Population epigenetics is an emerging field which has challenges in terms of methodology and interpretation of the data. Key challenges include tissue specificity, cell type adjustment, issues of power and comparability of findings, genetic influences, and exploring causality and functional consequences. Ongoing studies are working on addressing these issues. Large collaborative efforts of prospective cohorts are emerging, with clear benefits in terms of optimizing power and use of resources, and in advancing methodology. In the future, multidisciplinary approaches, within and beyond longitudinal birth and preconception cohorts will advance this complex, but highly promising, field of research.

U2 - 10.1017/S2040174418000442

DO - 10.1017/S2040174418000442

M3 - Review article

JO - Journal of Developmental Origins of Health and Disease

JF - Journal of Developmental Origins of Health and Disease

SN - 2040-1744

ER -

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