Positron detection in silica monoliths for miniaturised quality control of PET radiotracers

Mark D. Tarn; Dzmitry Maneuski; Richard Alexander; Nathaniel J. Brown; Val O'Shea; Sally L. Pimlott; Nicole Pamme; Stephen J. Archibald

doi:10.1039/c6cc00660d

Positron detection in silica monoliths for miniaturised quality control of PET radiotracers

Mark D. Tarn, Dzmitry Maneuski^*, Richard Alexander, Nathaniel J. Brown, Val O'Shea, Sally L. Pimlott, Nicole Pamme, Stephen J. Archibald

^*Corresponding author for this work

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [⁶⁸Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith.

Original language	English
Pages (from-to)	7221-7224
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	45
DOIs	https://doi.org/10.1039/c6cc00660d
Publication status	Published - 2016

Access to Document

10.1039/c6cc00660d

Cite this

@article{9b0832ee649647e88e1318c9ffff429d,

title = "Positron detection in silica monoliths for miniaturised quality control of PET radiotracers",

abstract = "We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [68Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith.",

author = "Tarn, {Mark D.} and Dzmitry Maneuski and Richard Alexander and Brown, {Nathaniel J.} and Val O'Shea and Pimlott, {Sally L.} and Nicole Pamme and Archibald, {Stephen J.}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6cc00660d",

language = "English",

volume = "52",

pages = "7221--7224",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "45",

}

TY - JOUR

T1 - Positron detection in silica monoliths for miniaturised quality control of PET radiotracers

AU - Tarn, Mark D.

AU - Maneuski, Dzmitry

AU - Alexander, Richard

AU - Brown, Nathaniel J.

AU - O'Shea, Val

AU - Pimlott, Sally L.

AU - Pamme, Nicole

AU - Archibald, Stephen J.

PY - 2016

Y1 - 2016

N2 - We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [68Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith.

AB - We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [68Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith.

UR - http://www.scopus.com/inward/record.url?scp=84971578009&partnerID=8YFLogxK

U2 - 10.1039/c6cc00660d

DO - 10.1039/c6cc00660d

M3 - Article

C2 - 27029282

AN - SCOPUS:84971578009

SN - 1359-7345

VL - 52

SP - 7221

EP - 7224

JO - Chemical Communications

JF - Chemical Communications

IS - 45

ER -

Positron detection in silica monoliths for miniaturised quality control of PET radiotracers

Abstract

Access to Document

Other files and links

Fingerprint

Cite this